171941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 318016..318540 Replicon chromosome
Accession NZ_CP061030
Organism Staphylococcus pseudintermedius strain Z0118SP0108

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag IAU63_RS01760 Protein ID WP_014613379.1
Coordinates 318016..318369 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag IAU63_RS01765 Protein ID WP_014613378.1
Coordinates 318370..318540 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU63_RS01740 315325..316095 - 771 WP_015729428.1 RNA polymerase sigma factor SigB -
IAU63_RS01745 316070..316549 - 480 WP_041614876.1 anti-sigma B factor RsbW -
IAU63_RS01750 316549..316875 - 327 WP_014613381.1 anti-sigma factor antagonist -
IAU63_RS01755 316954..317958 - 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
IAU63_RS01760 318016..318369 - 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IAU63_RS01765 318370..318540 - 171 WP_014613378.1 hypothetical protein Antitoxin
IAU63_RS01770 318625..319773 - 1149 WP_065354670.1 alanine racemase -
IAU63_RS01775 319807..320157 - 351 WP_014613376.1 holo-ACP synthase -
IAU63_RS01780 320154..320672 - 519 WP_110179271.1 PH domain-containing protein -
IAU63_RS01785 320656..322185 - 1530 WP_100006850.1 PH domain-containing protein -
IAU63_RS01790 322178..322651 - 474 WP_014613373.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T171941 WP_014613379.1 NZ_CP061030:c318369-318016 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T171941 NZ_CP079114:3267982-3268242 [Streptomyces sp. WY228]
GTGAAGTTCGTGTGGGACCAGTCGTCGTGGGACGACTACGTCTGGTGGCAGAACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACACTGCTCCAGGACATCGCCCGGAACGGCAACGAAGGAATGGGCAAGCCGGAACCCCTGAAGCACGGCTTCCACG
GGTACTGGTCCCGCCGCATCACCGATGAGCACCGGCTCATCTCCAAGGTGGTCGGCGACGAGGTCCGCATCGCCGCCTGC
CGCTACCACTACGGCAACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT171941 WP_014613378.1 NZ_CP061030:c318540-318370 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT171941 NZ_CP079114:3267734-3267985 [Streptomyces sp. WY228]
ATGCGCACGATGACCTACACGGAGTCCCGCGCGAAGTACGCCGAGACCCTGAGCGCGGTCGTGGACGACCGTGAAGAGGT
CGTGGTCACGCGTGCCGGGCACGAGCCCGTGGTGATAGTGGCTCTCGACGAGTACGAGTCCCTCAAGGAGACCGCGTACC
AGCTCCGGAGCCCGGAGAACGCCCGTCGGCTGCTGGCTTCGATCGACCGCCTGGAGAGCGGCGGCGGCACGGTGCAGGAG
CTTGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References