Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1478975..1479484 Replicon chromosome
Accession NZ_CP061029
Organism Staphylococcus epidermidis strain Z0118SE0132

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag IAU62_RS07225 Protein ID WP_002447767.1
Coordinates 1478975..1479184 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag IAU62_RS07230 Protein ID WP_002458700.1
Coordinates 1479191..1479484 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU62_RS07205 1474554..1475909 - 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IAU62_RS07210 1475921..1476994 - 1074 WP_002458698.1 D-alanine--D-alanine ligase -
IAU62_RS07215 1477385..1478596 + 1212 WP_002447766.1 rod shape-determining protein RodA -
IAU62_RS07220 1478695..1478832 - 138 WP_001829949.1 hypothetical protein -
IAU62_RS07225 1478975..1479184 - 210 WP_002447767.1 cation transporter Toxin
IAU62_RS07230 1479191..1479484 - 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
IAU62_RS07235 1479658..1481142 + 1485 WP_187759449.1 cardiolipin synthase -
IAU62_RS07240 1481324..1481977 + 654 WP_002495677.1 HD domain-containing protein -
IAU62_RS07245 1482084..1482956 - 873 WP_002458703.1 membrane protein insertase YidC -
IAU62_RS07250 1483045..1483683 - 639 WP_002458704.1 thiamine phosphate synthase -
IAU62_RS07255 1483689..1484477 - 789 WP_002486939.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T171937 WP_002447767.1 NZ_CP061029:c1479184-1478975 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T171937 NZ_CP079105:c3734530-3734270 [Skermania piniformis]
ATGCGGACGATGAGCTACAGCGAGTCGCGTGCCCGGTACGCCGAAGTTCTGGATTCGGTGGTCAACGACCGGGAGGAGAT
CGTGATCACCCGCGCGGGTCATGAGCCGGTGGTGATGGTCTCGTTGGCCGATTTCGAGTCGCTGCGGGAGACCGCCTATC
TGATGCGTTCACCGGCGAATGCCCGACGTCTGCTCGACGCGATGGAGCGGCTCGAGAGTGGTGCGGGAGAGGAGCGTCCG
CTTATCGATACGGCAGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT171937 WP_002458700.1 NZ_CP061029:c1479484-1479191 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT171937 NZ_CP079105:c3734267-3733992 [Skermania piniformis]
GTGCGGCTCGTGTGGGATGCCAACGCATGGGAGGACTACCTGTGGTGGCAGGCGCAGGATCGAAAAGTGCTCGGGCGGAT
CAACGCCCTCGTGGCGGATATCGTCCGAAACGGAAACGAAGGCATCGGTAAGCCCGAGCCGCTGAAGCATGACTTCGCGG
GGTACTGGTCCCGGAGAATTACCGACGAGCACCGCATGGTGTACAAGGTCGTCGCGTCCGAGGGCGCCGACACCGAGGTC
CGTATTGCGGCGTGCCGTTACCACTACGGACGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References