Detailed information of TA system TA171936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1467768..1468297
• Replicon: chromosome
• Accession: NZ_CP061029
• Organism: Staphylococcus epidermidis strain Z0118SE0132

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A939SRT1
• Locus tag: IAU62_RS07165
• Protein ID: WP_002447757.1
• Coordinates: 1467768..1468130 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q5HME6
• Locus tag: IAU62_RS07170
• Protein ID: WP_001829931.1
• Coordinates: 1468127..1468297 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU62_RS07145	1464769..1465539	-	771	WP_002447754.1	RNA polymerase sigma factor SigB	-
IAU62_RS07150	1465514..1465993	-	480	WP_002447755.1	anti-sigma B factor RsbW	-
IAU62_RS07155	1465995..1466321	-	327	WP_001829952.1	anti-sigma factor antagonist	-
IAU62_RS07160	1466421..1467422	-	1002	WP_002447756.1	PP2C family protein-serine/threonine phosphatase	-
IAU62_RS07165	1467768..1468130	-	363	WP_002447757.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IAU62_RS07170	1468127..1468297	-	171	WP_001829931.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
IAU62_RS07175	1468384..1469532	-	1149	WP_002475027.1	alanine racemase	-
IAU62_RS07180	1469599..1469952	-	354	WP_002447759.1	holo-ACP synthase	-
IAU62_RS07185	1469991..1470509	-	519	WP_002447760.1	PH domain-containing protein	-
IAU62_RS07190	1470496..1472001	-	1506	WP_002447761.1	PH domain-containing protein	-
IAU62_RS07195	1471994..1472473	-	480	WP_002447762.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13483.62 Da
• Isoelectric Point: 9.9522

>T171936 WP_002447757.1 NZ_CP061029:c1468130-1467768 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Nucleotide

• Length: 363 bp

>T171936 NZ_CP079105:c3734267-3733992 [Skermania piniformis]
GTGCGGCTCGTGTGGGATGCCAACGCATGGGAGGACTACCTGTGGTGGCAGGCGCAGGATCGAAAAGTGCTCGGGCGGAT
CAACGCCCTCGTGGCGGATATCGTCCGAAACGGAAACGAAGGCATCGGTAAGCCCGAGCCGCTGAAGCATGACTTCGCGG
GGTACTGGTCCCGGAGAATTACCGACGAGCACCGCATGGTGTACAAGGTCGTCGCGTCCGAGGGCGCCGACACCGAGGTC
CGTATTGCGGCGTGCCGTTACCACTACGGACGCTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6289.92 Da
• Isoelectric Point: 4.1920

>AT171936 WP_001829931.1 NZ_CP061029:c1468297-1468127 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Nucleotide

• Length: 171 bp

>AT171936 NZ_CP079105:c3734530-3734270 [Skermania piniformis]
ATGCGGACGATGAGCTACAGCGAGTCGCGTGCCCGGTACGCCGAAGTTCTGGATTCGGTGGTCAACGACCGGGAGGAGAT
CGTGATCACCCGCGCGGGTCATGAGCCGGTGGTGATGGTCTCGTTGGCCGATTTCGAGTCGCTGCGGGAGACCGCCTATC
TGATGCGTTCACCGGCGAATGCCCGACGTCTGCTCGACGCGATGGAGCGGCTCGAGAGTGGTGCGGGAGAGGAGCGTCCG
CTTATCGATACGGCAGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0N1EF65