Detailed information of TA system TA171935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1321986..1322791
• Replicon: chromosome
• Accession: NZ_CP061029
• Organism: Staphylococcus epidermidis strain Z0118SE0132

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: IAU62_RS06345
• Protein ID: WP_020361957.1
• Coordinates: 1321986..1322168 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A829M6U1
• Locus tag: IAU62_RS06350
• Protein ID: WP_020364054.1
• Coordinates: 1322192..1322791 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU62_RS06325	1317898..1318722	+	825	WP_002457882.1	RluA family pseudouridine synthase	-
IAU62_RS06330	1318896..1319378	-	483	Protein_1250	transposase	-
IAU62_RS06335	1319853..1321238	-	1386	WP_020361955.1	class II fumarate hydratase	-
IAU62_RS06340	1321430..1321834	-	405	WP_070846328.1	hypothetical protein	-
IAU62_RS06345	1321986..1322168	-	183	WP_020361957.1	hypothetical protein	Toxin
IAU62_RS06350	1322192..1322791	-	600	WP_020364054.1	glucosamine-6-phosphate isomerase	Antitoxin
IAU62_RS06355	1322949..1323419	-	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IAU62_RS06360	1323416..1324546	-	1131	WP_002476052.1	tRNA epoxyqueuosine(34) reductase QueG	-
IAU62_RS06365	1324894..1325616	-	723	WP_002446766.1	amino acid ABC transporter ATP-binding protein	-
IAU62_RS06370	1325609..1327066	-	1458	WP_002446767.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1318896..1319207	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7053.64 Da
• Isoelectric Point: 4.3016

>T171935 WP_020361957.1 NZ_CP061029:c1322168-1321986 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLSQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T171935 NZ_CP079099:c1297921-1297175 [Bacillus velezensis]
ATGCTTATGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22663.60 Da
• Isoelectric Point: 4.9942

>AT171935 WP_020364054.1 NZ_CP061029:c1322791-1322192 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAVGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT171935 NZ_CP079099:c1297174-1297004 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A829M6U1