Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 237267..238884 Replicon chromosome
Accession NZ_CP061008
Organism Achromobacter xylosoxidans strain GD03

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IAG39_RS01135 Protein ID WP_118932279.1
Coordinates 237532..238884 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A8G1X2V2
Locus tag IAG39_RS01130 Protein ID WP_054455917.1
Coordinates 237267..237527 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG39_RS01115 232921..233952 + 1032 WP_059377621.1 hypothetical protein -
IAG39_RS01120 233945..235849 + 1905 WP_118932277.1 Vi polysaccharide transport protein VexE -
IAG39_RS01125 235862..237082 + 1221 WP_118932278.1 polysaccharide lyase family 1 protein -
IAG39_RS01130 237267..237527 + 261 WP_054455917.1 helix-turn-helix domain-containing protein Antitoxin
IAG39_RS01135 237532..238884 + 1353 WP_118932279.1 type II toxin-antitoxin system HipA family toxin Toxin
IAG39_RS01140 238915..239682 - 768 WP_059376929.1 helix-turn-helix transcriptional regulator -
IAG39_RS01145 239775..240905 + 1131 WP_118932280.1 MFS transporter -
IAG39_RS01150 240923..242293 - 1371 WP_118932281.1 sensor histidine kinase N-terminal domain-containing protein -
IAG39_RS01155 242290..242961 - 672 WP_118932282.1 response regulator -
IAG39_RS01160 243088..243717 + 630 WP_059376938.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49161.22 Da        Isoelectric Point: 7.2609

>T171932 WP_118932279.1 NZ_CP061008:237532-238884 [Achromobacter xylosoxidans]
MGRRSHAQILGLWMNGTYVGEWSNRPHAGEVLQYDKDWVASAPGRPLSLSLPFTPGNGPHRGDVVRAYFENLLPDSKEIR
ERVARRFRAGSTDAFALLAEIGRDCAGALQILPAGTAPADVTSVQASPLNDAQVAQLLRSVPAPALLGGQAIAEDDFRIS
IAGAQEKTALLRMDGQWCLPQGATPTTHILKLPLGLVGNMKFDLSESVENEWLCSEILAAYGMPVARTEVLSFEDMKVLA
VERFDRRWQDGGDGARGLIRLPQEDMCQATGTPPHLKYEADGGPGIERIMSLLETSRHAEHDRRTFFQAQVLFWMLCATD
GHAKNFSLFLRPGGAYELTPLYDVLSAYPILGEGPGKLSPVRAKMAMAVRSKNPHWRMRDIQRRHWLTAGARHGVVTPDG
QGVQFVVDDLIARTPEAVRMVRARLPPGFPQAVADGILGGLQAAADRLAT

Download         Length: 1353 bp

>T171932 NZ_CP079097:c1899057-1898131 [Methylococcus capsulatus]
ATGAACCAGCGCAACATGGCCGCCTCGGTGCGCGCCCGCCTGCTCAACCGCGCCCGCGAGACCCGGCAAGACTTCAATCT
GATCTTGACCCGCTATGCGCTTGAGCGCCTGCTTTACCGGCTCAGCATCTCCCCCCACGCCGACCAGTTCCTGCTGAAAG
GTGCGCTGTTGTTCGATCTGTGGTTCGACATCCCGCATCGTCCGACACGCGACGCCGATCTGCTGGGCTTCGGCTCGGCC
GAGATTCCGCATGTCGAGGCGGCGTTTCGGGACGTCTGTACGGTGGAACTGGACGACGGCATACGCTTCCAGCCTGACTC
GGTACACGCGGAGGAGATCCGCAAGGAAGCCAACTACTCCGGTGTCCGGGTCACGCTGATCGGCCTGTTGGACGGTGCCC
GATGCCACGTGCAGGTCGACGTGGGTTTCGGCGACGCCGTGACGCCCGGCCCCGAGGCCGTCGACTACCCGGTGATGCTG
TCGGAGATGCCAGCCCCGAAGTTGCGTGCCTACCCCCGCTACACGGTCATCGCCGAGAAGCTGGAGGCGCTGGTGTCGCT
CGGTATCGCCAACAGCCGCATGAAGGATTACTTCGATCTCTGGATCTTGTCGCGCTACACTGACTTCGACGGCGCGCTCC
TGTGCAAGGCGATCCACGCCACCTTCGAGCGCCGCAGGACGCCGCTGCCGGATGGCGTCCCTTTCGGCCTGAGCGACGAA
TTCGCACAGGATCGGCAGAAGCAGACCCAGTGGCAGGCATTCTTGAGGAAGAATGCTTTGGTCGAGCTTCAGATCTCCGA
GGTCGTTGCCGTTCTGCGTGTATTCCTGTCGCCCCCGCTGGACGCGCTCCGGCAAGCTGCCGCTTTTCCGCAAACATGGC
TTGCCGGTAGCGGGTGGGCGTCCGGCAGCGAGGAATCGGGCCGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9305.68 Da        Isoelectric Point: 6.2389

>AT171932 WP_054455917.1 NZ_CP061008:237267-237527 [Achromobacter xylosoxidans]
IMDFTVRTATQLPALLQGFRKEAGLTQAATALRLGVTQQTLSALERNADKVSADRLLQLLSILGVEMVLRQQGAQPGPET
TSEPSW

Download         Length: 261 bp

>AT171932 NZ_CP079097:c1899689-1899054 [Methylococcus capsulatus]
TTGACAGCTACCGACGTTTCGCAACATTATGACGACATGGACAGTTCGCACCAGAGCATTCTGGATCTTGCCGCCCAGCG
CGGCCTTATTCGCCCACGCGATCTCAATGAGCGTGGGCTGCCCACGGTCGCCCTCACGCGGCTGGTGCGGCAAGGGCTGC
TCCAGCGCGTGGGACGGGGCCTGTACGCAATTCCGGACCGGACCGTCTCGGAACACGGCGCACTCGCCGAGGTGGCACGC
AAGCACCCGCAAGCCATCGTCTGCCTGCTGTCGGCACTGCGCCTACATGAACTCACCACACAGTCGCCGTTCGAGGTCTG
GCTGGCAATCCCCAACAAGGCACGCGCGCCAAAGATGGACTATCCCCCGCTGCGCATCGTGCGCTTCTCTGGCGCTGCGC
TGACGGAGGGGGTCGAGGAGCACCTCATCGATGGTGTGCCGGTGCGCGTGACCAACGTCGCCCGGACCGTGGCTGACTGC
TTCAAGTTCCGCAACAAGATCGGCCTTGATGTCGCGCTGGAGGCGCTACAGGAGTCCTGGCGTGCCAAGCGCGTCAGCAT
GGATGAACTTTGGCGTTTTGCTGCGCTGTGCCGTGTGGCCAATGTGATGCGCCCCTACATGGAAAGCCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References