Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2722573..2723096 Replicon chromosome
Accession NZ_CP061007
Organism Saccharopolyspora spinosa strain CCTCC M206084

Toxin (Protein)


Gene name relE Uniprot ID A0A2N3XQ03
Locus tag IAG28_RS11435 Protein ID WP_010316014.1
Coordinates 2722836..2723096 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N3XQ22
Locus tag IAG28_RS11430 Protein ID WP_029536196.1
Coordinates 2722573..2722839 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG28_RS11420 2719898..2721568 - 1671 WP_029536195.1 DNA polymerase Y family protein -
IAG28_RS11425 2721571..2722284 - 714 WP_010316009.1 hypothetical protein -
IAG28_RS11430 2722573..2722839 + 267 WP_029536196.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IAG28_RS11435 2722836..2723096 + 261 WP_010316014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAG28_RS11440 2723326..2724891 - 1566 WP_010316016.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
IAG28_RS11445 2724888..2725562 - 675 WP_083822375.1 phosphoribosylglycinamide formyltransferase -
IAG28_RS11450 2725660..2727114 - 1455 WP_148272123.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9539.08 Da        Isoelectric Point: 9.9079

>T171929 WP_010316014.1 NZ_CP061007:2722836-2723096 [Saccharopolyspora spinosa]
VTYTIKITARAGRDLALLPEKVAAACAEFIFGPLAESPHRLGKPLFGEFKGLHSARRSAYRVVYAIQDDTVVVEVVRIAH
RADVYR

Download         Length: 261 bp

>T171929 NZ_CP079095:c2556155-2555877 [Methylococcus sp. Mc7]
ATGATCCAGTCGTTCAAGCACAAGGGACTGTCCCGGTACTTCGCCGAGGACGATCACCGTGGCATCAACCCCAAACAGGC
AGCCCGTATCCGTCGCCTACTCGACCGACTGGACGCCGCAGCCCAGGCCGAAGACATGAACCTTCCCGGCTACGGGTTTC
ATGGACTCGCCCATAACCGGGCCGGCGAGTATGCCGTGACGGTTTCCGGAAACTGGCGGATCACTTTCCGCTTCGAGAGC
GGCCACGCCTTTGATGTGAACCTGGAGGACTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9579.68 Da        Isoelectric Point: 4.4159

>AT171929 WP_029536196.1 NZ_CP061007:2722573-2722839 [Saccharopolyspora spinosa]
MTTIPLGEARDRLSEVVAQVESTHDRVAITRHGRPAAVLISPDDLSSLEETLDLLTTPGEAEAIREGVADAAAGRFVDTE
EIKRHYLQ

Download         Length: 267 bp

>AT171929 NZ_CP079095:c2555877-2555575 [Methylococcus sp. Mc7]
ATGAAAAGCCTACGCCACGACCGGCGCAGACCCACCCACCCCGGCGAAGTGCTGCGGGAAGACGTTCTACCGGCGCTGGG
GATCACCCAGACCGAACTGGCCAAGCGGCTGATGGTAAGCCGCGTCACCGTTTCGGAAATCCTACTGGAGAAGCGGGCGC
TGTCACCTGACATGGCTGTTCGGATCAGCCGCTTGACCAGCACCACCCCCGAGAGCTGGCTGGCCATGCAGCAAGCGGTA
GACCTGTGGGAAGTGAATCAGCACCCGGAGCGTTACGCCGCTATCTCACCTGTGGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N3XQ03

Antitoxin

Source ID Structure
AlphaFold DB A0A2N3XQ22

References