Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3288886..3289539 Replicon chromosome
Accession NZ_CP060994
Organism Acinetobacter baumannii strain CAb-65

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag IAG34_RS16130 Protein ID WP_024437032.1
Coordinates 3288886..3289275 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag IAG34_RS16135 Protein ID WP_001288210.1
Coordinates 3289282..3289539 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG34_RS16110 (IAG34_16105) 3285409..3285975 - 567 WP_000651536.1 rhombosortase -
IAG34_RS16115 (IAG34_16110) 3286053..3286694 - 642 Protein_3160 hypothetical protein -
IAG34_RS16120 (IAG34_16115) 3286787..3287656 + 870 WP_217408632.1 IS982-like element ISAcsp2 family transposase -
IAG34_RS16125 (IAG34_16120) 3287672..3288118 - 447 Protein_3162 hypothetical protein -
IAG34_RS16130 (IAG34_16125) 3288886..3289275 - 390 WP_024437032.1 membrane protein Toxin
IAG34_RS16135 (IAG34_16130) 3289282..3289539 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
IAG34_RS16140 (IAG34_16135) 3289727..3290899 + 1173 WP_017725189.1 acyl-CoA dehydrogenase family protein -
IAG34_RS16145 (IAG34_16140) 3290948..3292438 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
IAG34_RS16150 (IAG34_16145) 3292620..3292997 - 378 WP_001216380.1 50S ribosomal protein L17 -
IAG34_RS16155 (IAG34_16150) 3293016..3294023 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3287054..3287656 602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T171924 WP_024437032.1 NZ_CP060994:c3289275-3288886 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T171924 NZ_CP079095:c1591441-1590689 [Methylococcus sp. Mc7]
TTGAGCGCGATATGGGCCGCCTGCCGCGACCAGGCGCCCCTTGGCCCGCTGCACGGTCACCTCTACCGGATGGTCGAAAG
CCAGGAACAGGTGGCGACCTATCGGATCGTGTCCTCCCTGGAAGAACAGGCCTTGCTGGAAGAACTCCTGGAGACGTCCA
AGCCCCCGCCGCCGGAAACCGCCGGGGATTTCCATTACCTGCTCACGACCCCCTTCCGCTACCCGCCCCTCCGCCATGGC
TCTCGCTTTGGCCGGCGGCACGAACCCGGCCTGTTCTATGGTTCGGCCACCGTCGACACGATGCTGGCGGAAGTTGCCTA
CTACCGCTTCGTGTTTTGGCAAGGCATGGAAACGCCGCCTCAAACACCCATCGTCACCCAGCACACCGTATTCAGCGCAC
GCTATGCGTGCGGCAGGGGGCTGAAACTGCAAGATCCGCCGTTCGACGCCTGGCGCGCGACGTTGACCGACCCCAGGCAC
TATGCGCCCACCCAGGACCTGGGAAGCGCGATGAGAGAAGCCGGTGTTCAGGCGTTCGAGTACCTGTCGGCACGCGATCC
GGCAGCGGGAATCAACGTCGCCTTGTTTGAGCCCGCTGCGCTGGCCAGCCAACGGCCGATCGAATGCCAGAACTGGCTCG
CGGAAACCTCGGGGGAACACGTGGCGTTCCTGGGGGAAGCGAGGCAGATTCGAGGTTTCGAGCTTGAAACCTTCCTGGTC
GAGGGTATGTTGCCTGCGCCAGCCGTTTGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT171924 WP_001288210.1 NZ_CP060994:c3289539-3289282 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT171924 NZ_CP079095:c1591797-1591438 [Methylococcus sp. Mc7]
ATGAATACCGTAGCCAAGGCCAAGCCGGAGCCCTCATCCGTTTTGGGACACGCCTTTCTGGAGGCTGGCAGGAAACTCGG
GCTGAGCCAGTCGGTACTGGAGGTCACGATTGCTCGCAACCGGAGTTCGATCAGCCGCAACGGCATCGACCCGGACAGCA
AATCCGGGGAATTGGCGCTGCTGCTGATCCGGATTTACCGGTCCCTGTTTGCGCTGATGGGGGGCGATGAAGCGCAGATG
GCGCACTGGATGAAGACCCGCAATCGGCACACCGGCGGCATTCCGGCGGAACAGATCCGCAGCGTTCAAGGCCTGGTGGG
CGTTGTGGAATACCTCGACGCCATGCGAGGGAAAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References