Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 697620..698298 Replicon chromosome
Accession NZ_CP060994
Organism Acinetobacter baumannii strain CAb-65

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IAG34_RS03365 Protein ID WP_000009390.1
Coordinates 698119..698298 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IAG34_RS03360 Protein ID WP_109104350.1
Coordinates 697620..698033 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAG34_RS03320 (IAG34_03315) 692878..693198 + 321 WP_000312237.1 multidrug efflux SMR transporter -
IAG34_RS03325 (IAG34_03320) 693210..693689 + 480 WP_000927489.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
IAG34_RS03330 (IAG34_03325) 693826..695046 + 1221 WP_000268130.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
IAG34_RS03335 (IAG34_03330) 695193..696257 + 1065 WP_001278262.1 quinolinate synthase NadA -
IAG34_RS03360 (IAG34_03355) 697620..698033 - 414 WP_109104350.1 antitoxin Antitoxin
IAG34_RS03365 (IAG34_03360) 698119..698298 - 180 WP_000009390.1 type II toxin-antitoxin system HicA family toxin Toxin
IAG34_RS03370 (IAG34_03365) 698399..698629 - 231 WP_228732846.1 hypothetical protein -
IAG34_RS03375 (IAG34_03370) 698640..699686 - 1047 WP_109104349.1 phage portal protein -
IAG34_RS03380 (IAG34_03375) 699683..701461 - 1779 WP_109104348.1 terminase family protein -
IAG34_RS03385 (IAG34_03380) 701640..702497 + 858 WP_109104347.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 697620..754964 57344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(16-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6799.11 Da        Isoelectric Point: 11.1422

>T171923 WP_000009390.1 NZ_CP060994:c698298-698119 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Download         Length: 180 bp

>T171923 NZ_CP079095:c1279366-1279118 [Methylococcus sp. Mc7]
ATGCGTGAATGGGCATTGCAAGACGCCAAAGCGCGTTTGAGTGAAGTCGTGCGGCTGGCGATGGAGCACGAACCGCAAGA
AATTACCTTACGCGGTGAGCCGGCGGTGGTGGTGCTGTCCATGGAGGACTACCGCCGTTTGGTCCACCCGAAACCGAGTT
TCGTGGAACTCATCCGCAGTTCACCATTGATGGATGTGGACATCGACCTGACCCGCGAGCAATCGATGACGCGGGAAGTC
GACCTGTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15343.71 Da        Isoelectric Point: 6.4890

>AT171923 WP_109104350.1 NZ_CP060994:c698033-697620 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYAVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFHALGKDLDIVIA

Download         Length: 414 bp

>AT171923 NZ_CP079095:c1279052-1278627 [Methylococcus sp. Mc7]
GTGAGCAACGGCGGGGGATTTTTACTCGATACCAACATCGTATCGGAACTACGCCGCAAACAGCCCGAACCGCGTGTATT
GCGATGGTTCGAGCAGGTCAGCGATGACAAGCTGTATCTCAGCGTACTTACGATTGGCGAAATCCGTCGCGGCATCGCGC
GCCTGACTGACCCGGCACAGCAACACCGTCTGACTGACTGGCTGGAAGGCACGCTGTTCCCTTGGCTGGGTTCGCAGTTG
TTGCCGGTGAACCTTGCTGTCGCCGAGTGCTGGGGCCGCTTGTGCGGTGCGGCCGGCCGCCCGTTGCCCACCATCGACAG
CCTGCTCGCCGCTACCGCCGTCGAACACGGATTGACGCTCGTCACCCGCAATGCGGCGGATTTCCAGTTTGCCGGTCTGC
AGGTCTTTAACCCTTGGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References