171913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4365960..4366555 Replicon chromosome
Accession NZ_CP060987
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H9212_RS21235 Protein ID WP_000239579.1
Coordinates 4365960..4366310 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H9212_RS21240 Protein ID WP_001223208.1
Coordinates 4366304..4366555 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9212_RS21215 (4361406) 4361406..4362428 - 1023 WP_001295197.1 ABC transporter permease -
H9212_RS21220 (4362442) 4362442..4363944 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
H9212_RS21225 (4364084) 4364084..4365040 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H9212_RS21230 (4365350) 4365350..4365880 + 531 WP_000055072.1 inorganic diphosphatase -
H9212_RS21235 (4365960) 4365960..4366310 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H9212_RS21240 (4366304) 4366304..4366555 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H9212_RS21245 (4366767) 4366767..4367108 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H9212_RS21250 (4367111) 4367111..4370890 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T171913 WP_000239579.1 NZ_CP060987:c4366310-4365960 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T171913 NZ_CP078521:c1987747-1987571 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT171913 WP_001223208.1 NZ_CP060987:c4366555-4366304 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT171913 NZ_CP078521:1987448-1987503 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References