171898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1964099..1964934 Replicon chromosome
Accession NZ_CP060987
Organism Escherichia coli strain EC31

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H9212_RS09565 Protein ID WP_042046912.1
Coordinates 1964099..1964476 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H9212_RS09570 Protein ID WP_073961352.1
Coordinates 1964566..1964934 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9212_RS09545 (1960837) 1960837..1961583 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
H9212_RS09550 (1961598) 1961598..1963139 - 1542 WP_002431311.1 IS21-like element ISEc12 family transposase -
H9212_RS09555 (1963773) 1963773..1963853 - 81 Protein_1884 hypothetical protein -
H9212_RS09560 (1963953) 1963953..1964102 - 150 Protein_1885 DUF5983 family protein -
H9212_RS09565 (1964099) 1964099..1964476 - 378 WP_042046912.1 TA system toxin CbtA family protein Toxin
H9212_RS09570 (1964566) 1964566..1964934 - 369 WP_073961352.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9212_RS09575 (1965097) 1965097..1965318 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9212_RS09580 (1965381) 1965381..1965857 - 477 WP_001186774.1 RadC family protein -
H9212_RS09585 (1965873) 1965873..1966346 - 474 WP_000855059.1 antirestriction protein -
H9212_RS09590 (1966688) 1966688..1967506 - 819 WP_106504503.1 DUF932 domain-containing protein -
H9212_RS09595 (1967624) 1967624..1967819 - 196 Protein_1892 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galF / cpsACP / wzi / wza / gmd / wcaG / wcaJ / gnd / manC / manB / ugd 1801822..2025363 223541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14020.96 Da        Isoelectric Point: 7.8276

>T171898 WP_042046912.1 NZ_CP060987:c1964476-1964099 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T171898 NZ_CP078163:c6799-5936 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAATACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
AGATAAAGGGTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGATTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGGATTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13444.17 Da        Isoelectric Point: 6.2050

>AT171898 WP_073961352.1 NZ_CP060987:c1964934-1964566 [Escherichia coli]
VSDTLSGATHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171898 NZ_CP078163:c7073-6801 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References