Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2447..2969 Replicon plasmid pEC3-5
Accession NZ_CP060983
Organism Escherichia coli strain EC3

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag H9191_RS24590 Protein ID WP_000220561.1
Coordinates 2688..2969 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag H9191_RS24585 Protein ID WP_000121743.1
Coordinates 2447..2698 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9191_RS24580 (H9191_24360) 74..1081 - 1008 WP_000243325.1 replication initiation protein -
H9191_RS24585 (H9191_24365) 2447..2698 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
H9191_RS24590 (H9191_24370) 2688..2969 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9191_RS24595 (H9191_24375) 2993..3343 + 351 WP_000312755.1 hypothetical protein -
H9191_RS24600 (H9191_24380) 3983..4498 + 516 WP_001025397.1 J domain-containing protein -
H9191_RS24605 (H9191_24385) 4603..5145 + 543 WP_001083906.1 hypothetical protein -
H9191_RS24610 (H9191_24390) 5142..5393 + 252 WP_001230707.1 hypothetical protein -
H9191_RS24615 (H9191_24395) 5380..5607 + 228 WP_000801440.1 hypothetical protein -
H9191_RS24620 (H9191_24400) 6061..6360 + 300 WP_000650310.1 hypothetical protein -
H9191_RS24625 (H9191_24405) 6455..6805 + 351 WP_000854260.1 hypothetical protein -
H9191_RS24630 (H9191_24410) 7110..7358 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
H9191_RS24635 (H9191_24415) 7355..7702 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35307 35307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T171888 WP_000220561.1 NZ_CP060983:2688-2969 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T171888 NZ_CP078162:c312349-312254 [Enterococcus faecalis]
ATGTACGACATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT171888 WP_000121743.1 NZ_CP060983:2447-2698 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT171888 NZ_CP078162:312154-312219 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References