Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1849431..1850266 Replicon chromosome
Accession NZ_CP060979
Organism Escherichia coli strain EC3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag H9191_RS09055 Protein ID WP_000854761.1
Coordinates 1849431..1849808 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag H9191_RS09060 Protein ID WP_001295723.1
Coordinates 1849898..1850266 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9191_RS09015 (1844697) 1844697..1845755 + 1059 WP_001200892.1 FUSC family protein -
H9191_RS09020 (1845927) 1845927..1846256 + 330 WP_000450409.1 DUF496 family protein -
H9191_RS09025 (1846357) 1846357..1846722 - 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
H9191_RS09030 (1846993) 1846993..1847364 - 372 WP_001295631.1 IS110 family transposase -
H9191_RS09035 (1847571) 1847571..1847795 - 225 Protein_1775 transposase -
H9191_RS09040 (1847973) 1847973..1848675 + 703 Protein_1776 IS66-like element ISEc22 family transposase -
H9191_RS09045 (1849106) 1849106..1849186 - 81 Protein_1777 hypothetical protein -
H9191_RS09050 (1849286) 1849286..1849434 - 149 Protein_1778 DUF5983 family protein -
H9191_RS09055 (1849431) 1849431..1849808 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
H9191_RS09060 (1849898) 1849898..1850266 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9191_RS09065 (1850429) 1850429..1850650 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9191_RS09070 (1850952) 1850952..1851521 + 570 WP_000221554.1 inovirus Gp2 family protein -
H9191_RS09075 (1851687) 1851687..1852079 + 393 WP_001352248.1 putative zinc ribbon protein -
H9191_RS09080 (1852089) 1852089..1853057 - 969 Protein_1784 IS110 family transposase -
H9191_RS09085 (1853242) 1853242..1853646 + 405 WP_001221631.1 zinc-ribbon domain-containing protein -
H9191_RS09090 (1853937) 1853937..1854599 + 663 Protein_1786 ISL3 family transposase -
H9191_RS09095 (1854663) 1854663..1854923 + 261 Protein_1787 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1847985..1848671 686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T171858 WP_000854761.1 NZ_CP060979:c1849808-1849431 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T171858 NZ_CP078142:817575-817988 [Salmonella enterica subsp. diarizonae]
GTGGTCCTGTGGCAATCTGAATTACGCGTCTCATGGCGCGCTCAGTGGATCTCGTTGCTTATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCATTGTGGATGATGCTACTGTCGCTGGTCGTGTTTGACTGCG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAAATCAAGCTGCTAATGGATGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTTTTGCGTCCGCCCTGGTTACTGAGGAGCGGGATGGTGTTGCGTTTACGCGCTGAGTCTGGGCACCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGCAGCGGAATGGCGTGAGTTGCGTCGGATAATGTTACAGCAACCAATAT
CGCGCCAACACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT171858 WP_001295723.1 NZ_CP060979:c1850266-1849898 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171858 NZ_CP078142:817328-817594 [Salmonella enterica subsp. diarizonae]
ATGGACATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGCGACGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References