Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832256..832910 Replicon chromosome
Accession NZ_CP060979
Organism Escherichia coli strain EC3

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag H9191_RS04090 Protein ID WP_000244777.1
Coordinates 832503..832910 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H9191_RS04085 Protein ID WP_000354046.1
Coordinates 832256..832522 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9191_RS04060 (827425) 827425..828168 + 744 WP_000951962.1 SDR family oxidoreductase -
H9191_RS04065 (828225) 828225..829658 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
H9191_RS04070 (829703) 829703..830014 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H9191_RS04075 (830178) 830178..830837 + 660 WP_000250274.1 hemolysin III family protein -
H9191_RS04080 (831033) 831033..832013 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H9191_RS04085 (832256) 832256..832522 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H9191_RS04090 (832503) 832503..832910 + 408 WP_000244777.1 protein YgfX Toxin
H9191_RS04095 (832950) 832950..833471 - 522 WP_001055874.1 flavodoxin FldB -
H9191_RS04100 (833583) 833583..834479 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H9191_RS04105 (834504) 834504..835214 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9191_RS04110 (835220) 835220..836953 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T171855 WP_000244777.1 NZ_CP060979:832503-832910 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T171855 NZ_CP078140:c36927-36634 [Pseudomonas savastanoi pv. savastanoi]
ATGCTACCCATTTTCTGGCTAGAATCAGCGGACAACGATTTGGCGGCAATAATCGAATACATAGGTTTATGTGATATAGC
TGCTGCCGAAAGGTTGTGGCAGCGCTTGCGTAGCATCGTTCTGCCCCTTTCAGAACATCCTTATCTGTATGCGATAAGTG
ACCGCGTTCCAGGAATGCGCGAGATCGTGGCCCATCCTAACTACCTGGTGTTTTATCGCGTCACCTCAACGCGCATAGAA
GTGGTGAACGTCGTCCACGCACGGCAAGAATATCCCCAAACTGGACTAGCGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT171855 WP_000354046.1 NZ_CP060979:832256-832522 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171855 NZ_CP078140:c37112-36927 [Pseudomonas savastanoi pv. savastanoi]
ATGGTTGATCGTTCGCCTATCGTTTCGGAGTTTGAAACTGAAGAGCTAGAGGCCAATTACACCGCCTGGCTACGCGCGAA
GGTGGAGGCAAGTCTGGCCGACTCGCGCCCTGCTATCCCGCATGATGAAGTCGAGCGAAGGATGGCAGAGCGGTTGGCAC
GATTGCGCCATCGCCGAGCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References