Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2334855..2335381 | Replicon | chromosome |
| Accession | NZ_CP060974 | ||
| Organism | Escherichia coli strain EC4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | H9192_RS11335 | Protein ID | WP_000323025.1 |
| Coordinates | 2335094..2335381 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | H9192_RS11330 | Protein ID | WP_000534858.1 |
| Coordinates | 2334855..2335094 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9192_RS11295 (2330214) | 2330214..2330561 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| H9192_RS11300 (2330558) | 2330558..2330962 | - | 405 | WP_000839179.1 | transposase | - |
| H9192_RS11305 (2331184) | 2331184..2331605 | + | 422 | Protein_2218 | hypothetical protein | - |
| H9192_RS11310 (2332261) | 2332261..2333283 | + | 1023 | Protein_2219 | ISNCY family transposase | - |
| H9192_RS11315 (2333404) | 2333404..2333553 | + | 150 | WP_011443592.1 | protein YdfW | - |
| H9192_RS11320 (2333990) | 2333990..2334322 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| H9192_RS11325 (2334525) | 2334525..2334830 | - | 306 | WP_001326990.1 | protein YdfV | - |
| H9192_RS11330 (2334855) | 2334855..2335094 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| H9192_RS11335 (2335094) | 2335094..2335381 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| H9192_RS11340 (2335453) | 2335453..2335608 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| H9192_RS11345 (2335825) | 2335825..2336076 | + | 252 | WP_000980994.1 | protein Rem | - |
| H9192_RS11350 (2336143) | 2336143..2336421 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| H9192_RS11355 (2336423) | 2336423..2337472 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| H9192_RS11360 (2337486) | 2337486..2338238 | + | 753 | WP_001047135.1 | antitermination protein | - |
| H9192_RS11365 (2338516) | 2338516..2338605 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| H9192_RS11370 (2338660) | 2338660..2338872 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| H9192_RS11375 (2339032) | 2339032..2340012 | - | 981 | WP_000019440.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2311333..2399595 | 88262 | |
| - | flank | IS/Tn | - | - | 2339032..2340012 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T171832 WP_000323025.1 NZ_CP060974:2335094-2335381 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T171832 NZ_CP078137:806190-806588 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT171832 WP_000534858.1 NZ_CP060974:2334855-2335094 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT171832 NZ_CP078137:805963-806190 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|