Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1877432..1878263 Replicon chromosome
Accession NZ_CP060974
Organism Escherichia coli strain EC4

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H9192_RS08920 Protein ID WP_000854814.1
Coordinates 1877432..1877806 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H9192_RS08925 Protein ID WP_001285585.1
Coordinates 1877895..1878263 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9192_RS08880 (1872828) 1872828..1873994 + 1167 WP_000830144.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H9192_RS08885 (1874113) 1874113..1874586 + 474 WP_001105416.1 DNA gyrase inhibitor SbmC -
H9192_RS08890 (1874784) 1874784..1875842 + 1059 WP_001200890.1 FUSC family protein -
H9192_RS08895 (1876014) 1876014..1876343 + 330 WP_000450409.1 DUF496 family protein -
H9192_RS08900 (1876444) 1876444..1876578 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
H9192_RS08905 (1876698) 1876698..1876826 + 129 Protein_1747 transposase domain-containing protein -
H9192_RS08910 (1877115) 1877115..1877195 - 81 Protein_1748 hypothetical protein -
H9192_RS08915 (1877241) 1877241..1877435 - 195 WP_000988600.1 DUF5983 family protein -
H9192_RS08920 (1877432) 1877432..1877806 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
H9192_RS08925 (1877895) 1877895..1878263 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
H9192_RS08930 (1878337) 1878337..1878558 - 222 WP_000692323.1 DUF987 domain-containing protein -
H9192_RS08935 (1878621) 1878621..1879097 - 477 WP_001186773.1 RadC family protein -
H9192_RS08940 (1879113) 1879113..1879592 - 480 WP_000860081.1 antirestriction protein -
H9192_RS08945 (1879674) 1879674..1880495 - 822 WP_048217813.1 DUF932 domain-containing protein -
H9192_RS08950 (1880716) 1880716..1881126 - 411 WP_000846713.1 hypothetical protein -
H9192_RS08955 (1881142) 1881142..1881825 - 684 WP_000775500.1 hypothetical protein -
H9192_RS08960 (1881961) 1881961..1883031 - 1071 WP_000102644.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T171823 WP_000854814.1 NZ_CP060974:c1877806-1877432 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171823 NZ_CP078131:20946-21290 [Lactiplantibacillus plantarum subsp. plantarum]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCGCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTGGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT171823 WP_001285585.1 NZ_CP060974:c1878263-1877895 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT171823 NZ_CP078131:20689-20952 [Lactiplantibacillus plantarum subsp. plantarum]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References