Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 789508..790306 Replicon chromosome
Accession NZ_CP060974
Organism Escherichia coli strain EC4

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag H9192_RS03830 Protein ID WP_000854735.1
Coordinates 789508..789885 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag H9192_RS03835 Protein ID WP_032153712.1
Coordinates 789932..790306 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9192_RS03795 (785071) 785071..786249 + 1179 WP_241461897.1 type II secretion system protein GspL -
H9192_RS03800 (786251) 786251..786787 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
H9192_RS03805 (787202) 787202..787528 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
H9192_RS03810 (787525) 787525..787788 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
H9192_RS03815 (787860) 787860..788726 - 867 WP_032153714.1 DUF4942 domain-containing protein -
H9192_RS03820 (788811) 788811..789008 - 198 WP_000839265.1 DUF957 domain-containing protein -
H9192_RS03825 (789020) 789020..789511 - 492 WP_023155722.1 DUF5983 family protein -
H9192_RS03830 (789508) 789508..789885 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
H9192_RS03835 (789932) 789932..790306 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
H9192_RS03840 (790386) 790386..790607 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9192_RS03845 (790676) 790676..791152 - 477 WP_001186715.1 RadC family protein -
H9192_RS03850 (791168) 791168..791653 - 486 WP_032153711.1 antirestriction protein -
H9192_RS03855 (791745) 791745..792563 - 819 WP_001234693.1 DUF932 domain-containing protein -
H9192_RS03860 (792654) 792654..792863 - 210 WP_023155727.1 DUF905 family protein -
H9192_RS03865 (792893) 792893..793570 - 678 WP_023155728.1 hypothetical protein -
H9192_RS03870 (793689) 793689..794573 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 787525..855749 68224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T171819 WP_000854735.1 NZ_CP060974:c789885-789508 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T171819 NZ_CP078124:19062-19505 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT171819 WP_032153712.1 NZ_CP060974:c790306-789932 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT171819 NZ_CP078124:18835-19065 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References