Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4238308..4238903 Replicon chromosome
Accession NZ_CP060969
Organism Escherichia coli strain EC5

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H9193_RS20595 Protein ID WP_000239579.1
Coordinates 4238308..4238658 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H9193_RS20600 Protein ID WP_001223208.1
Coordinates 4238652..4238903 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9193_RS20575 (4233757) 4233757..4234779 - 1023 WP_001353963.1 ABC transporter permease -
H9193_RS20580 (4234793) 4234793..4236295 - 1503 WP_000210557.1 sugar ABC transporter ATP-binding protein -
H9193_RS20585 (4236435) 4236435..4237391 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H9193_RS20590 (4237701) 4237701..4238231 + 531 WP_000055072.1 inorganic diphosphatase -
H9193_RS20595 (4238308) 4238308..4238658 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H9193_RS20600 (4238652) 4238652..4238903 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H9193_RS20605 (4239115) 4239115..4239456 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H9193_RS20610 (4239459) 4239459..4243238 - 3780 WP_053276653.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T171801 WP_000239579.1 NZ_CP060969:c4238658-4238308 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T171801 NZ_CP078120:c3084169-3083906 [Halomonas sp. 18071143]
ATGAACGAGTTCGAGTTTGACGTCAACAAAAGTCAGGCCAACCTGACAAAGCACGGTATTGATTTTGAAGCGGCACAAGC
GCTGTGGAAGGATCCATATCTGCTAGAAATTCGCGCAAAATCCGAGGGCGAACCAAGGTTTTTACTAATCGGTATGATCA
GTGAAAAACATTGGTCGGCAGTCGTCACCTACCGAGAAGAGCGTATTCGGCTGATTTCTGTTAGACGCTCCCGCAAGAAG
GAGGTAGACATCTATGAAAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT171801 WP_001223208.1 NZ_CP060969:c4238903-4238652 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT171801 NZ_CP078120:c3083916-3083647 [Halomonas sp. 18071143]
ATGAAAGCTAAAGAGTTCGATAAAAAATTCGATGAAAATCAAGATGATGTTCTCGATGATCTAGACTTTTCCACTGCTCG
ACGGGTGAATCAGGAGCAAAAGCGGATTAACGTAGATTTTCCTGCATGGGTAGTGGAGTCACTAGACCGTGAGGCTGCGA
GAATGGGTGTTACCCGCCAGTCGATTATCAAGGTTTGGTTAGTGGAGCGTCTGCAAGCTGAAGCGGCTCATAAACCTCAT
GGCCATAACTCAGTAGGGGGACCTCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References