Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4142208..4143043 | Replicon | chromosome |
| Accession | NZ_CP060969 | ||
| Organism | Escherichia coli strain EC5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2S4A272 |
| Locus tag | H9193_RS20115 | Protein ID | WP_001094443.1 |
| Coordinates | 4142208..4142585 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7LDN9 |
| Locus tag | H9193_RS20120 | Protein ID | WP_001285607.1 |
| Coordinates | 4142675..4143043 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9193_RS20080 (4137421) | 4137421..4138527 | + | 1107 | WP_001353974.1 | N-acetylneuraminate epimerase | - |
| H9193_RS20085 (4138592) | 4138592..4139572 | + | 981 | WP_001295601.1 | sialate O-acetylesterase | - |
| H9193_RS20090 (4139580) | 4139580..4140230 | - | 651 | WP_001037966.1 | HNH endonuclease | - |
| H9193_RS20095 (4140367) | 4140367..4140510 | + | 144 | Protein_3951 | HNH endonuclease | - |
| H9193_RS20100 (4141278) | 4141278..4141421 | - | 144 | Protein_3952 | hypothetical protein | - |
| H9193_RS20105 (4141506) | 4141506..4141703 | - | 198 | WP_001327226.1 | DUF957 domain-containing protein | - |
| H9193_RS20110 (4141723) | 4141723..4142211 | - | 489 | WP_000761685.1 | DUF5983 family protein | - |
| H9193_RS20115 (4142208) | 4142208..4142585 | - | 378 | WP_001094443.1 | TA system toxin CbtA family protein | Toxin |
| H9193_RS20120 (4142675) | 4142675..4143043 | - | 369 | WP_001285607.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H9193_RS20125 (4143123) | 4143123..4143344 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| H9193_RS20130 (4143431) | 4143431..4143907 | - | 477 | WP_001186165.1 | RadC family protein | - |
| H9193_RS20135 (4143922) | 4143922..4144407 | - | 486 | WP_000206664.1 | antirestriction protein | - |
| H9193_RS20140 (4144499) | 4144499..4145317 | - | 819 | WP_001175163.1 | DUF932 domain-containing protein | - |
| H9193_RS20145 (4145407) | 4145407..4145640 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| H9193_RS20150 (4145646) | 4145646..4146323 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| H9193_RS20155 (4146471) | 4146471..4147151 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fimE / fimB | 4132808..4168324 | 35516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14058.97 Da Isoelectric Point: 7.3523
>T171800 WP_001094443.1 NZ_CP060969:c4142585-4142208 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T171800 NZ_CP078120:2821987-2822241 [Halomonas sp. 18071143]
ATGAAGCTCATCTTTTCCGAGAACGCCTGGGAAGACTATTTATACTGGCAGAAAACTGACAAAAAGATTCTCAACCGAAT
CAACAAGCTAGTCAAAGAAATCAAGCGAGAGCCATTTGAAGGAGTCGGCAAGCCAGAACCCCTTAAACACAGCCTCGCGG
GTTACTGGTCTCGGCGAATCAACGAAGAACACCGCATCGTTTACAAGGTCACGGACGACGCTTTGCTTGTTGCCCAACTG
CGGTATCACTACTGA
ATGAAGCTCATCTTTTCCGAGAACGCCTGGGAAGACTATTTATACTGGCAGAAAACTGACAAAAAGATTCTCAACCGAAT
CAACAAGCTAGTCAAAGAAATCAAGCGAGAGCCATTTGAAGGAGTCGGCAAGCCAGAACCCCTTAAACACAGCCTCGCGG
GTTACTGGTCTCGGCGAATCAACGAAGAACACCGCATCGTTTACAAGGTCACGGACGACGCTTTGCTTGTTGCCCAACTG
CGGTATCACTACTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13689.53 Da Isoelectric Point: 6.4669
>AT171800 WP_001285607.1 NZ_CP060969:c4143043-4142675 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT171800 NZ_CP078120:2821739-2821990 [Halomonas sp. 18071143]
ATGGATGCCATCAGCTACACCGCCGCTAGAACCAACCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCACTCTCCTGT
GATCATCACCCGCAATAAGGCGCAATCCGTGGTCATGATCTCTCTCGAAGACTATGAAGCACTGCAAGAGACAGCCTACC
TCCTGCGCGCGCCCAAAAACGCCCGCCGTTTACTGGAATCCGTTGCCGAGTTGGAGCAAGGGGGCGGTCAGGAAAAGGAG
CTTCTTGAATGA
ATGGATGCCATCAGCTACACCGCCGCTAGAACCAACCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCACTCTCCTGT
GATCATCACCCGCAATAAGGCGCAATCCGTGGTCATGATCTCTCTCGAAGACTATGAAGCACTGCAAGAGACAGCCTACC
TCCTGCGCGCGCCCAAAAACGCCCGCCGTTTACTGGAATCCGTTGCCGAGTTGGAGCAAGGGGGCGGTCAGGAAAAGGAG
CTTCTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S4A272 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0JLU8 |