Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2913513..2914357 Replicon chromosome
Accession NZ_CP060969
Organism Escherichia coli strain EC5

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag H9193_RS14280 Protein ID WP_000854686.1
Coordinates 2913513..2913896 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag H9193_RS14285 Protein ID WP_001285602.1
Coordinates 2913977..2914357 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9193_RS14240 (2908515) 2908515..2909006 - 492 WP_001300785.1 DUF1097 domain-containing protein -
H9193_RS14245 (2909108) 2909108..2909662 - 555 WP_001001921.1 molecular chaperone YcdY -
H9193_RS14250 (2909686) 2909686..2910423 - 738 WP_000283667.1 zinc-binding phosphatase -
H9193_RS14255 (2910478) 2910478..2911416 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
H9193_RS14265 (2911887) 2911887..2912729 - 843 WP_001431817.1 DUF4942 domain-containing protein -
H9193_RS14270 (2912814) 2912814..2913011 - 198 WP_000839253.1 DUF957 domain-containing protein -
H9193_RS14275 (2913028) 2913028..2913516 - 489 WP_001054233.1 DUF5983 family protein -
H9193_RS14280 (2913513) 2913513..2913896 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
H9193_RS14285 (2913977) 2913977..2914357 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9193_RS14290 (2914368) 2914368..2915051 - 684 WP_000086768.1 hypothetical protein -
H9193_RS14295 (2915070) 2915070..2915291 - 222 WP_000692298.1 DUF987 domain-containing protein -
H9193_RS14300 (2915354) 2915354..2915830 - 477 WP_001186726.1 RadC family protein -
H9193_RS14305 (2915846) 2915846..2916331 - 486 WP_000214307.1 antirestriction protein -
H9193_RS14310 (2916423) 2916423..2917241 - 819 WP_001234732.1 DUF932 domain-containing protein -
H9193_RS14315 (2917341) 2917341..2917574 - 234 WP_001119717.1 DUF905 family protein -
H9193_RS14320 (2917653) 2917653..2918108 - 456 WP_001504120.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T171796 WP_000854686.1 NZ_CP060969:c2913896-2913513 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T171796 NZ_CP078120:c2707917-2707666 [Halomonas sp. 18071143]
ATGAAAACGATCACTTACCGTAAAAGCGCGTTGAAGGTGTTGCAGCGAATGCCGCGACCTGAGTCGAAGCGCATACAAGG
CAAAATCAAGGCCTATGCGGAAGACCCGGAAAGCCAGCGCAACAATGTGAAGGCCTTGAAGGGGAGCGATTATATTCGGC
TGCGGGTAGGCGACTGGCGGGTGATCATCGACGAGCATGGCGATGTACTCGACATTATTAACATCGGTGCCCGTGGCGGC
GTTTATCAATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT171796 WP_001285602.1 NZ_CP060969:c2914357-2913977 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT171796 NZ_CP078120:c2707627-2707265 [Halomonas sp. 18071143]
ATGAGCATACCTCAAATTATTCAAACGCCCACGGGCGAGCGGTTAGTGGTTCTGCCTGAGCAGGAGTACCAAGCGTTGCT
TGCGCGGCTGGAAGACCAGGACGATATTGACGCTGCCAACGCGGTGGTGGCGCGTGGTGAAGAGTCATTTCCTGTGGCGG
TTGTGGATGCGCTGCTGGATGGCGTGGCACCCGTGAAGGTGTACCGCGAATACCGTGGACTACGTGCAGGTGAGCTGGCG
GAAAAAGCAGGGATCAGCCAAGGGTACCTTTCCGAAATAGAGTCAGGGAAAAAAAGCGGCTCGTTGAGTGTGCTGACCCG
TATTGCGACTGCTTTAGAGGTTGAACTGAGCGACCTTACCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References