Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2376449..2378037 Replicon chromosome
Accession NZ_CP060969
Organism Escherichia coli strain EC5

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag H9193_RS11560 Protein ID WP_001125439.1
Coordinates 2376715..2378037 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H9193_RS11555 Protein ID WP_001301023.1
Coordinates 2376449..2376715 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9193_RS11555 (2376449) 2376449..2376715 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H9193_RS11560 (2376715) 2376715..2378037 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
H9193_RS11565 (2378349) 2378349..2378557 + 209 Protein_2268 AraC family transcriptional regulator -
H9193_RS11570 (2378812) 2378812..2380038 + 1227 Protein_2269 fimbria/pilus outer membrane usher protein -
H9193_RS11575 (2380052) 2380052..2380582 + 531 WP_000876784.1 fimbrial protein -
H9193_RS11580 (2380595) 2380595..2381098 + 504 WP_000825452.1 fimbrial protein -
H9193_RS11585 (2381158) 2381158..2382072 + 915 WP_044864589.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T171794 WP_001125439.1 NZ_CP060969:2376715-2378037 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T171794 NZ_CP078120:c2535733-2535452 [Halomonas sp. 18071143]
ATGAGCACGCTGCGTAAATGGGATGTCGTTGACCACTTGAATACCGAAGAGGAAATGGTGTTGTACTTTGAAGCCTGCCT
TGAAGAGGGCGACGCTGCCCTGGTGGCGGCAGCGCTTGGCGATATTGCCCGCGCCCGTGGTATGGCACAGCTTGCTCGTG
ATACGGGGTTGACTCGCGAAGGGTTGTACAAGGCGCTTTCTGCTGATGGAAACCCAAGTTTTGCAACGATTATGAAGGTG
ACAAAAGCCTTGGGCTTTACGTTACGTGCTGAAGTATCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT171794 WP_001301023.1 NZ_CP060969:2376449-2376715 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT171794 NZ_CP078120:c2536032-2535730 [Halomonas sp. 18071143]
ATGAAAATAATTAGCGAAACCGACACTTATTCGGACTGGTTCGATAAATTACGCGATGCTCGGGCCAGAGCGAAAATTCT
GGCTCGTCTGCGCCGGGCTGAGCTGGGCAACTTCGGGGATTGTGAGCCGGTGGGGGAAGGAGTCTCGGAATTGAGGATTC
ACTACGGGCCTGGTTATCGAGTCTATTTTGTCCAGCGGGGGTATGAGCTGATTATTTTGTTGGCGGGCGGTGATAAATCC
AGCCAGGCAAAAGATATTGATATCGCGAAGCAATTGGCACGCGATTTGAAGGAGGCACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References