Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4362032..4362867 | Replicon | chromosome |
| Accession | NZ_CP060963 | ||
| Organism | Escherichia coli strain EC7 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | H9194_RS21580 | Protein ID | WP_029402447.1 |
| Coordinates | 4362490..4362867 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3Z2YIX3 |
| Locus tag | H9194_RS21575 | Protein ID | WP_032178229.1 |
| Coordinates | 4362032..4362400 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9194_RS21535 (4357133) | 4357133..4358017 | + | 885 | WP_023563932.1 | 50S ribosome-binding GTPase | - |
| H9194_RS21540 (4358136) | 4358136..4358813 | + | 678 | WP_001097368.1 | hypothetical protein | - |
| H9194_RS21545 (4358819) | 4358819..4359052 | + | 234 | WP_032288847.1 | DUF905 family protein | - |
| H9194_RS21550 (4359142) | 4359142..4359960 | + | 819 | WP_024214765.1 | DUF932 domain-containing protein | - |
| H9194_RS21555 (4360052) | 4360052..4360537 | + | 486 | WP_071045790.1 | antirestriction protein | - |
| H9194_RS21560 (4360553) | 4360553..4361029 | + | 477 | WP_001186771.1 | RadC family protein | - |
| H9194_RS21565 (4361098) | 4361098..4361319 | + | 222 | WP_113847077.1 | DUF987 domain-containing protein | - |
| H9194_RS21570 (4361338) | 4361338..4361982 | + | 645 | WP_113847078.1 | antitoxin of toxin-antitoxin stability system | - |
| H9194_RS21575 (4362032) | 4362032..4362400 | + | 369 | WP_032178229.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H9194_RS21580 (4362490) | 4362490..4362867 | + | 378 | WP_029402447.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| H9194_RS21585 (4362864) | 4362864..4363013 | + | 150 | Protein_4242 | DUF5983 family protein | - |
| H9194_RS21590 (4363089) | 4363089..4363286 | + | 198 | WP_097471913.1 | DUF957 domain-containing protein | - |
| H9194_RS21595 (4363371) | 4363371..4364237 | + | 867 | WP_024257423.1 | DUF4942 domain-containing protein | - |
| H9194_RS21600 (4364309) | 4364309..4364572 | + | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| H9194_RS21605 (4364569) | 4364569..4364895 | + | 327 | WP_000779482.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H9194_RS21610 (4365778) | 4365778..4367316 | + | 1539 | WP_001187173.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4345280..4375128 | 29848 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13900.92 Da Isoelectric Point: 8.5163
>T171767 WP_029402447.1 NZ_CP060963:4362490-4362867 [Escherichia coli]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T171767 NZ_CP078110:c3274098-3273682 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGTTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGTCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATCACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCGAAAACGACGCGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCGGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCA
TAGGCGACAAACGCTAA
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGTTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGTCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATCACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCGAAAACGACGCGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCGGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCA
TAGGCGACAAACGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13823.58 Da Isoelectric Point: 6.3177
>AT171767 WP_032178229.1 NZ_CP060963:4362032-4362400 [Escherichia coli]
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLHETNYPDDNNDRSWWGLPCTVTPCFRARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT171767 NZ_CP078110:c3274345-3274079 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|