Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2311266..2311792 | Replicon | chromosome |
| Accession | NZ_CP060963 | ||
| Organism | Escherichia coli strain EC7 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | H9194_RS11395 | Protein ID | WP_000323025.1 |
| Coordinates | 2311505..2311792 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | H9194_RS11390 | Protein ID | WP_000534858.1 |
| Coordinates | 2311266..2311505 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9194_RS11355 (2306994) | 2306994..2307224 | - | 231 | Protein_2227 | IS66 family insertion sequence element accessory protein TnpB | - |
| H9194_RS11360 (2307230) | 2307230..2307352 | - | 123 | Protein_2228 | transposase | - |
| H9194_RS11365 (2307595) | 2307595..2308016 | + | 422 | Protein_2229 | hypothetical protein | - |
| H9194_RS11370 (2308672) | 2308672..2309694 | + | 1023 | Protein_2230 | ISNCY family transposase | - |
| H9194_RS11375 (2309815) | 2309815..2309964 | + | 150 | WP_011443592.1 | protein YdfW | - |
| H9194_RS11380 (2310401) | 2310401..2310733 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| H9194_RS11385 (2310936) | 2310936..2311241 | - | 306 | WP_001326990.1 | protein YdfV | - |
| H9194_RS11390 (2311266) | 2311266..2311505 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| H9194_RS11395 (2311505) | 2311505..2311792 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| H9194_RS11400 (2311864) | 2311864..2312019 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| H9194_RS11405 (2312236) | 2312236..2312487 | + | 252 | WP_000980994.1 | protein Rem | - |
| H9194_RS11410 (2312554) | 2312554..2312832 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| H9194_RS11415 (2312834) | 2312834..2313883 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| H9194_RS11420 (2313897) | 2313897..2314649 | + | 753 | WP_001047135.1 | antitermination protein | - |
| H9194_RS11425 (2314927) | 2314927..2315016 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| H9194_RS11430 (2315071) | 2315071..2315283 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| H9194_RS11435 (2315584) | 2315584..2315799 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| H9194_RS11440 (2316163) | 2316163..2316333 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| H9194_RS11445 (2316553) | 2316553..2316768 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2295319..2329630 | 34311 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T171760 WP_000323025.1 NZ_CP060963:2311505-2311792 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T171760 NZ_CP078110:c959673-959455 [Cronobacter sakazakii]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAGCTCTACGATAAAATTCCGACCGCCGTGTGGAAGTTCGTTCGTTAA
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAGCTCTACGATAAAATTCCGACCGCCGTGTGGAAGTTCGTTCGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT171760 WP_000534858.1 NZ_CP060963:2311266-2311505 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT171760 NZ_CP078110:c960074-959700 [Cronobacter sakazakii]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCCGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCCGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|