Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1797548..1798379 Replicon chromosome
Accession NZ_CP060963
Organism Escherichia coli strain EC7

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H9194_RS08625 Protein ID WP_192847775.1
Coordinates 1797548..1797922 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag H9194_RS08630 Protein ID WP_001313071.1
Coordinates 1798011..1798379 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9194_RS08585 (1792944) 1792944..1794110 + 1167 WP_001310935.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H9194_RS08590 (1794229) 1794229..1794702 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
H9194_RS08595 (1794900) 1794900..1795958 + 1059 WP_001200905.1 FUSC family protein -
H9194_RS08600 (1796130) 1796130..1796459 + 330 WP_000450409.1 DUF496 family protein -
H9194_RS08605 (1796560) 1796560..1796784 - 225 WP_000917607.1 EutP/PduV family microcompartment system protein -
H9194_RS08610 (1796796) 1796796..1796942 + 147 Protein_1689 transposase domain-containing protein -
H9194_RS08615 (1797231) 1797231..1797311 - 81 Protein_1690 hypothetical protein -
H9194_RS08620 (1797357) 1797357..1797551 - 195 WP_000988600.1 DUF5983 family protein -
H9194_RS08625 (1797548) 1797548..1797922 - 375 WP_192847775.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
H9194_RS08630 (1798011) 1798011..1798379 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9194_RS08635 (1798459) 1798459..1798680 - 222 WP_000692323.1 DUF987 domain-containing protein -
H9194_RS08640 (1798743) 1798743..1799219 - 477 WP_001186773.1 RadC family protein -
H9194_RS08645 (1799235) 1799235..1799714 - 480 WP_000860076.1 antirestriction protein -
H9194_RS08650 (1799796) 1799796..1800617 - 822 WP_001234530.1 DUF932 domain-containing protein -
H9194_RS08655 (1800838) 1800838..1801248 - 411 WP_000846713.1 hypothetical protein -
H9194_RS08660 (1801264) 1801264..1801947 - 684 WP_000775500.1 hypothetical protein -
H9194_RS08665 (1802083) 1802083..1803153 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13900.91 Da        Isoelectric Point: 7.8522

>T171751 WP_192847775.1 NZ_CP060963:c1797922-1797548 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171751 NZ_CP078094:324595-324936 [Enterococcus lactis]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTGTGGATTGATTTTGATCCTTCGGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAGTTTAATCGTAAAACAATGTTTTCGGTCATATGTCCGATTA
CTTCCACGATAAAGAATTTACCGACACGTTACTCATTACCAGAAGAGCTAGATATAAAAGGACAAGTACTTATTTCTCAA
TTAAAATCACTTGATTTTAAGGAACGAAGACTCAAAAAAATAGAAAACCTGCCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAATATATGTTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT171751 WP_001313071.1 NZ_CP060963:c1798379-1798011 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT171751 NZ_CP078094:324365-324595 [Enterococcus lactis]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTTACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTATATTCTGACGATGGGACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GAGAAGAGGCCGAATATTATGAAAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAAGGTTATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References