Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3255093..3255925 Replicon chromosome
Accession NZ_CP060953
Organism Escherichia coli strain EC8

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag H9195_RS15665 Protein ID WP_000854753.1
Coordinates 3255093..3255467 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag H9195_RS15670 Protein ID WP_001540478.1
Coordinates 3255557..3255925 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9195_RS15645 (3251446) 3251446..3252984 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
H9195_RS15650 (3253733) 3253733..3254302 - 570 WP_001560692.1 DUF4942 domain-containing protein -
H9195_RS15655 (3254399) 3254399..3254596 - 198 WP_000839281.1 DUF957 domain-containing protein -
H9195_RS15660 (3254608) 3254608..3255096 - 489 WP_000777545.1 DUF5983 family protein -
H9195_RS15665 (3255093) 3255093..3255467 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
H9195_RS15670 (3255557) 3255557..3255925 - 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9195_RS15675 (3256088) 3256088..3256309 - 222 WP_000692311.1 DUF987 domain-containing protein -
H9195_RS15680 (3256372) 3256372..3256848 - 477 WP_001186786.1 RadC family protein -
H9195_RS15685 (3256864) 3256864..3257349 - 486 WP_000214398.1 antirestriction protein -
H9195_RS15690 (3257440) 3257440..3258258 - 819 WP_001773857.1 DUF932 domain-containing protein -
H9195_RS15695 (3258348) 3258348..3258581 - 234 WP_001278283.1 DUF905 family protein -
H9195_RS15700 (3258587) 3258587..3259264 - 678 WP_001097301.1 hypothetical protein -
H9195_RS15705 (3259412) 3259412..3260092 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3243633..3301293 57660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T171731 WP_000854753.1 NZ_CP060953:c3255467-3255093 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T171731 NZ_CP078069:847172-847468 [Comamonas sp. NLF-1-9]
GTGTACGAAGTCCTCAAAAGCAGCACGTTCGACAGCTGGCTCCGTGGCCTGCGTGACCGAGACGCGAAAGCCAGGATCGA
GGTTCGCATCAGGCGTCTTTCTCTTGGGAATCCCGGCCAGTTTCGGGCGCTCAAAGAAGGCGTCAATGAGCTCAAGATCG
ATCACGGCCCCGGCTACCGCGTCTATTACACGTTCAAGGGCAAGACGCTGATCCTGTTGCTTTGCGGCGGGGACAAGTCC
TCGCAAGGCAAGGACATACGACTCGCCATGGATATCGCCGCTTCCTGGGAGAACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT171731 WP_001540478.1 NZ_CP060953:c3255925-3255557 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171731 NZ_CP078069:847471-847764 [Comamonas sp. NLF-1-9]
ATGGCCAAAGCCAAAGAAACCTTCACCCGCTACGACACCGCCGACTATCTCGAGACCGAAGAAGACATTGCGGCCTATCT
CACCGCTTGCGCTGAAGAAGATGATCCGGCGCTCTTTCTTGCCGCCCTGGGCGATGTGGCGCGTGCCCGCAATATCACCC
AGCTCGCTGCCCAAACTGGCCTGACCCGCATGGGCCTCTACAAGGCTTTGTCTGGCACGGGCAATCCGAGCTTCGCTACC
GTCAGCAAGGTGGCGCACGCCCTGGGGCTGAGAATCACGGTAGCTGCTGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References