Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3263278..3263896 Replicon chromosome
Accession NZ_CP060950
Organism Escherichia coli strain EC9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H9196_RS15685 Protein ID WP_001291435.1
Coordinates 3263278..3263496 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H9196_RS15690 Protein ID WP_000344800.1
Coordinates 3263522..3263896 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9196_RS15650 (3258568) 3258568..3259140 + 573 WP_000779826.1 YbaY family lipoprotein -
H9196_RS15655 (3259171) 3259171..3259482 - 312 WP_000409911.1 MGMT family protein -
H9196_RS15665 (3259861) 3259861..3260214 + 354 WP_000878140.1 DUF1428 domain-containing protein -
H9196_RS15670 (3260256) 3260256..3261806 - 1551 WP_024166621.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H9196_RS15675 (3261970) 3261970..3262440 - 471 WP_000136192.1 YlaC family protein -
H9196_RS15680 (3262556) 3262556..3263107 - 552 WP_000102556.1 maltose O-acetyltransferase -
H9196_RS15685 (3263278) 3263278..3263496 - 219 WP_001291435.1 HHA domain-containing protein Toxin
H9196_RS15690 (3263522) 3263522..3263896 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H9196_RS15695 (3264442) 3264442..3267591 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H9196_RS15700 (3267614) 3267614..3268807 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T171695 WP_001291435.1 NZ_CP060950:c3263496-3263278 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171695 NZ_CP078030:c9813-9493 [Acinetobacter variabilis]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT171695 WP_000344800.1 NZ_CP060950:c3263896-3263522 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT171695 NZ_CP078030:c9500-9228 [Acinetobacter variabilis]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References