Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2529828..2530423 Replicon chromosome
Accession NZ_CP060950
Organism Escherichia coli strain EC9

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H9196_RS12150 Protein ID WP_000239579.1
Coordinates 2530073..2530423 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H9196_RS12145 Protein ID WP_001223208.1
Coordinates 2529828..2530079 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9196_RS12135 (2525492) 2525492..2529271 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
H9196_RS12140 (2529274) 2529274..2529615 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H9196_RS12145 (2529828) 2529828..2530079 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H9196_RS12150 (2530073) 2530073..2530423 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H9196_RS12155 (2530503) 2530503..2531033 - 531 WP_000055070.1 inorganic diphosphatase -
H9196_RS12160 (2531343) 2531343..2532299 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H9196_RS12165 (2532439) 2532439..2533941 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
H9196_RS12170 (2533955) 2533955..2534977 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T171692 WP_000239579.1 NZ_CP060950:2530073-2530423 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T171692 NZ_CP078029:c10574-10284 [Acinetobacter variabilis]
ATGCGGACGATTAAGTACACATCAGCATTCAAGAAAGACTATAAGCGTGAGAAAAAAGGGCAGCATCGAAATACAGTAGA
TGCTGAACTACAAACTGTTTTAGAGTTATTGCAAGCTGATGAAACCTTGCCTGAAAAGTATCGTGACCATGCTTTGGTCA
GTAATTGGGTAGGTCATCGTGACTGCCATATCAAACCAGATCTTGTTTTGATCTATAAAAAAACAGAGGAAGGAGAACTA
CTAATTTTGAAATTAGTTCGGTTAGGTAGTCATAGTGAATTAGCGATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT171692 WP_001223208.1 NZ_CP060950:2529828-2530079 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT171692 NZ_CP078029:c10821-10561 [Acinetobacter variabilis]
ATGGCTTCAAATTCACTAGTAACTACTCGCATTAATGAAAACATTAAGCATGAAGCAACAGAAGTTCTTGCAACAATGGG
CTTAACTGTCTCAGATGCAGTTCGCTTGTTGTTAACCAAAGTCGCGAAAGAAAAGGCCCTGCCTTTTGAAATTTGGCAAC
CCAGTGCTGAAACCATTGCTGCAATGGAAGAAGATCTAAGCAAAGCAAAGAGCTTCACTTCTGTAAAAGATTTGATGGCT
GATCTAAATGCGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References