Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1679442..1680028 Replicon chromosome
Accession NZ_CP060950
Organism Escherichia coli strain EC9

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag H9196_RS08175 Protein ID WP_042014162.1
Coordinates 1679798..1680028 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H9196_RS08170 Protein ID WP_000593555.1
Coordinates 1679442..1679801 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9196_RS08145 (1675574) 1675574..1676518 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
H9196_RS08150 (1676515) 1676515..1677348 + 834 WP_001008968.1 nickel ABC transporter permease subunit NikC -
H9196_RS08155 (1677348) 1677348..1678112 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
H9196_RS08160 (1678109) 1678109..1678915 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
H9196_RS08165 (1678921) 1678921..1679322 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H9196_RS08170 (1679442) 1679442..1679801 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H9196_RS08175 (1679798) 1679798..1680028 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
H9196_RS08180 (1680132) 1680132..1681256 - 1125 WP_241407715.1 ABC transporter permease -
H9196_RS08185 (1681256) 1681256..1683991 - 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T171689 WP_042014162.1 NZ_CP060950:c1680028-1679798 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T171689 NZ_CP078028:24948-25250 [Acinetobacter variabilis]
ATGTACTCAATATACACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCAGCAGGCAAAAAGGCGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCAGTCGGTGAAGGTGTCTCTGAATTACGCTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAACTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT171689 WP_000593555.1 NZ_CP060950:c1679801-1679442 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT171689 NZ_CP078028:25251-25532 [Acinetobacter variabilis]
ATGGCTATCAAACTTCGTAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATAGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACAGGTTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTC
ATTAAAGTGGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References