Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 573551..574176 Replicon chromosome
Accession NZ_CP060950
Organism Escherichia coli strain EC9

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag H9196_RS02720 Protein ID WP_000911329.1
Coordinates 573551..573949 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H9196_RS02725 Protein ID WP_000450524.1
Coordinates 573949..574176 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9196_RS02700 (569429) 569429..569629 + 201 WP_000383836.1 YpfN family protein -
H9196_RS02705 (569739) 569739..570437 - 699 WP_000679823.1 esterase -
H9196_RS02710 (570511) 570511..572526 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
H9196_RS02715 (572541) 572541..573404 - 864 WP_001267498.1 neutral zinc metallopeptidase -
H9196_RS02720 (573551) 573551..573949 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
H9196_RS02725 (573949) 573949..574176 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9196_RS02730 (574330) 574330..575043 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H9196_RS02735 (575256) 575256..576290 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H9196_RS02740 (576307) 576307..577185 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H9196_RS02745 (577331) 577331..577903 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H9196_RS02750 (577903) 577903..578373 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T171685 WP_000911329.1 NZ_CP060950:c573949-573551 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T171685 NZ_CP078019:174309-174590 [Acinetobacter junii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT171685 WP_000450524.1 NZ_CP060950:c574176-573949 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT171685 NZ_CP078019:174006-174308 [Acinetobacter junii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References