Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 7749..8392 Replicon chromosome
Accession NZ_CP060950
Organism Escherichia coli strain EC9

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag H9196_RS00030 Protein ID WP_001034046.1
Coordinates 7749..8165 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag H9196_RS00035 Protein ID WP_001261278.1
Coordinates 8162..8392 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9196_RS00015 (2886) 2886..3302 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
H9196_RS00020 (3299) 3299..3529 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
H9196_RS00025 (3910) 3910..7704 + 3795 WP_241407768.1 pcar -
H9196_RS00030 (7749) 7749..8165 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
H9196_RS00035 (8162) 8162..8392 - 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H9196_RS00040 (8657) 8657..9157 + 501 WP_000528931.1 HEPN family nuclease -
H9196_RS00045 (9170) 9170..9943 + 774 WP_000905949.1 hypothetical protein -
H9196_RS00050 (10110) 10110..11243 + 1134 WP_000545987.1 DUF3800 domain-containing protein -
H9196_RS00055 (11277) 11277..11765 - 489 WP_011254646.1 hypothetical protein -
H9196_RS00060 (12329) 12329..12679 + 351 WP_000493378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T171684 WP_001034046.1 NZ_CP060950:c8165-7749 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T171684 NZ_CP078019:174006-174308 [Acinetobacter junii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT171684 WP_001261278.1 NZ_CP060950:c8392-8162 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT171684 NZ_CP078019:174309-174590 [Acinetobacter junii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References