Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1038371..1039169 Replicon chromosome
Accession NZ_CP060933
Organism Escherichia coli strain EC12

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag H9199_RS05130 Protein ID WP_000854735.1
Coordinates 1038371..1038748 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag H9199_RS05135 Protein ID WP_032153712.1
Coordinates 1038795..1039169 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9199_RS05090 (1033587) 1033587..1033937 + 351 Protein_988 type II secretion system protein GspK -
H9199_RS05095 (1033934) 1033934..1035112 + 1179 WP_000094974.1 type II secretion system protein GspL -
H9199_RS05100 (1035114) 1035114..1035650 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
H9199_RS05105 (1036065) 1036065..1036391 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
H9199_RS05110 (1036388) 1036388..1036651 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
H9199_RS05115 (1036723) 1036723..1037589 - 867 WP_032153714.1 DUF4942 domain-containing protein -
H9199_RS05120 (1037674) 1037674..1037871 - 198 WP_000839265.1 DUF957 domain-containing protein -
H9199_RS05125 (1037883) 1037883..1038374 - 492 WP_023155722.1 DUF5983 family protein -
H9199_RS05130 (1038371) 1038371..1038748 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
H9199_RS05135 (1038795) 1038795..1039169 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
H9199_RS05140 (1039249) 1039249..1039470 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9199_RS05145 (1039539) 1039539..1040015 - 477 WP_001186715.1 RadC family protein -
H9199_RS05150 (1040031) 1040031..1040516 - 486 WP_032153711.1 antirestriction protein -
H9199_RS05155 (1040608) 1040608..1041426 - 819 WP_001234693.1 DUF932 domain-containing protein -
H9199_RS05160 (1041517) 1041517..1041726 - 210 WP_023155727.1 DUF905 family protein -
H9199_RS05165 (1041756) 1041756..1042433 - 678 WP_023155728.1 hypothetical protein -
H9199_RS05170 (1042552) 1042552..1043436 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 1036388..1104882 68494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T171594 WP_000854735.1 NZ_CP060933:c1038748-1038371 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T171594 NZ_CP077988:3676700-3677278 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT171594 WP_032153712.1 NZ_CP060933:c1039169-1038795 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT171594 NZ_CP077988:3676057-3676611 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References