Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1174144..1174975 Replicon chromosome
Accession NZ_CP060928
Organism Escherichia coli strain EC13

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H9200_RS05985 Protein ID WP_000854814.1
Coordinates 1174601..1174975 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H9200_RS05980 Protein ID WP_001285585.1
Coordinates 1174144..1174512 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9200_RS05945 (1169376) 1169376..1170446 + 1071 WP_000102643.1 patatin-like phospholipase family protein -
H9200_RS05950 (1170582) 1170582..1171265 + 684 WP_000775500.1 hypothetical protein -
H9200_RS05955 (1171281) 1171281..1171691 + 411 WP_000846713.1 hypothetical protein -
H9200_RS05960 (1171912) 1171912..1172733 + 822 WP_001234530.1 DUF932 domain-containing protein -
H9200_RS05965 (1172815) 1172815..1173294 + 480 WP_000860076.1 antirestriction protein -
H9200_RS05970 (1173310) 1173310..1173786 + 477 WP_001186773.1 RadC family protein -
H9200_RS05975 (1173849) 1173849..1174070 + 222 WP_000692323.1 DUF987 domain-containing protein -
H9200_RS05980 (1174144) 1174144..1174512 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
H9200_RS05985 (1174601) 1174601..1174975 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
H9200_RS05990 (1174972) 1174972..1175166 + 195 WP_000988600.1 DUF5983 family protein -
H9200_RS05995 (1175212) 1175212..1175292 + 81 Protein_1180 hypothetical protein -
H9200_RS06000 (1175581) 1175581..1175727 - 147 Protein_1181 transposase domain-containing protein -
H9200_RS06005 (1175739) 1175739..1175963 + 225 WP_000917607.1 EutP/PduV family microcompartment system protein -
H9200_RS06010 (1176064) 1176064..1176393 - 330 WP_000450409.1 DUF496 family protein -
H9200_RS06015 (1176565) 1176565..1177623 - 1059 WP_001200905.1 FUSC family protein -
H9200_RS06020 (1177821) 1177821..1178294 - 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
H9200_RS06025 (1178413) 1178413..1179579 - 1167 WP_000830163.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T171569 WP_000854814.1 NZ_CP060928:1174601-1174975 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171569 NZ_CP077973:c9720-9445 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAAGGGCTCTCCGACGTGGCACGGCTCTACGAGTTCCTGGCTACGGTGAACAGGGAAGC
TGCCGCCCGCACGGTGCAGCAGCTGACGAGCGCGCCGACCGCCTTGTTGACCAACCCGCGGCTGGGCGAGCGCCTGGAAG
AGTTCGAACCGCGGGATGTTCGCCGCATCCTGATCGGCCACTATGAGATGCGCTATGAGATCCTGGATTCCTGCATCTAC
GTGCTTCGTCTGTGGCACACACGCGAAGACAGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT171569 WP_001285585.1 NZ_CP060928:1174144-1174512 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT171569 NZ_CP077973:c9995-9720 [Pseudomonas aeruginosa]
ATGAGCACAGCAGCCAAACCAACGCGTACCGTGACTGCTCACGTCCCGGTAGATCTGGCCGAGCGCGTCGATGCAATCGC
CGAGCGCCTGGAGCGATCGAAGAACTGGATCGTCAGGCAGGCGCTGTCAGCCTGGATCGACCAGGAAGACGAGCGTAGCC
GTCTGACACGTGAAGCCTTGGATGATGTAGACGCAGGACGTGTCGTCGACCACCAGGCCGTCCAGGCCTGGGCCGAAAGC
CTGGGCACTGACTCTCCGCTGCCGGTACCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References