Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 699008..699534 | Replicon | chromosome |
| Accession | NZ_CP060928 | ||
| Organism | Escherichia coli strain EC13 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | H9200_RS03505 | Protein ID | WP_000323025.1 |
| Coordinates | 699008..699295 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | H9200_RS03510 | Protein ID | WP_000534858.1 |
| Coordinates | 699295..699534 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9200_RS03455 (694032) | 694032..694247 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| H9200_RS03460 (694467) | 694467..694637 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| H9200_RS03465 (695001) | 695001..695216 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| H9200_RS03470 (695517) | 695517..695729 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| H9200_RS03475 (695784) | 695784..695873 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| H9200_RS03480 (696151) | 696151..696903 | - | 753 | WP_001047135.1 | antitermination protein | - |
| H9200_RS03485 (696917) | 696917..697966 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| H9200_RS03490 (697968) | 697968..698246 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| H9200_RS03495 (698313) | 698313..698564 | - | 252 | WP_000980994.1 | protein Rem | - |
| H9200_RS03500 (698781) | 698781..698936 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| H9200_RS03505 (699008) | 699008..699295 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| H9200_RS03510 (699295) | 699295..699534 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| H9200_RS03515 (699559) | 699559..699864 | + | 306 | WP_001326990.1 | protein YdfV | - |
| H9200_RS03520 (700067) | 700067..700399 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| H9200_RS03525 (700836) | 700836..700985 | - | 150 | WP_011443592.1 | protein YdfW | - |
| H9200_RS03530 (701106) | 701106..702128 | - | 1023 | Protein_698 | ISNCY family transposase | - |
| H9200_RS03535 (702918) | 702918..703205 | - | 288 | Protein_699 | hypothetical protein | - |
| H9200_RS03540 (703448) | 703448..703570 | + | 123 | Protein_700 | transposase | - |
| H9200_RS03545 (703576) | 703576..703806 | + | 231 | Protein_701 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 667624..727203 | 59579 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T171560 WP_000323025.1 NZ_CP060928:c699295-699008 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T171560 NZ_CP077969:c4449068-4448811 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT171560 WP_000534858.1 NZ_CP060928:c699534-699295 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT171560 NZ_CP077969:c4448799-4448254 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|