Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4170899..4171734 Replicon chromosome
Accession NZ_CP060924
Organism Escherichia coli strain EC14

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag H9201_RS20205 Protein ID WP_000854759.1
Coordinates 4170899..4171276 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag H9201_RS20210 Protein ID WP_001295723.1
Coordinates 4171366..4171734 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9201_RS20180 (4167408) 4167408..4168945 + 1538 WP_085950854.1 IS3 family transposase -
H9201_RS20185 (4169423) 4169423..4169599 - 177 Protein_3959 helix-turn-helix domain-containing protein -
H9201_RS20190 (4169966) 4169966..4170115 - 150 Protein_3960 hypothetical protein -
H9201_RS20195 (4170221) 4170221..4170397 - 177 WP_000839286.1 DUF957 domain-containing protein -
H9201_RS20200 (4170414) 4170414..4170902 - 489 WP_000761690.1 DUF5983 family protein -
H9201_RS20205 (4170899) 4170899..4171276 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
H9201_RS20210 (4171366) 4171366..4171734 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9201_RS20215 (4171897) 4171897..4172118 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9201_RS20220 (4172181) 4172181..4172657 - 477 WP_001186775.1 RadC family protein -
H9201_RS20225 (4172673) 4172673..4173146 - 474 WP_000855059.1 antirestriction protein -
H9201_RS20230 (4173486) 4173486..4174304 - 819 WP_042631095.1 DUF932 domain-containing protein -
H9201_RS20235 (4174422) 4174422..4174617 - 196 Protein_3969 DUF905 family protein -
H9201_RS20240 (4174688) 4174688..4175713 - 1026 Protein_3970 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T171544 WP_000854759.1 NZ_CP060924:c4171276-4170899 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T171544 NZ_CP077969:1426763-1426939 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT171544 WP_001295723.1 NZ_CP060924:c4171734-4171366 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171544 NZ_CP077969:1426985-1427401 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References