Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1369218..1369843 Replicon chromosome
Accession NZ_CP060924
Organism Escherichia coli strain EC14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H9201_RS06665 Protein ID WP_000911330.1
Coordinates 1369445..1369843 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H9201_RS06660 Protein ID WP_000450524.1
Coordinates 1369218..1369445 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9201_RS06635 (1365021) 1365021..1365491 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H9201_RS06640 (1365491) 1365491..1366063 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H9201_RS06645 (1366209) 1366209..1367087 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H9201_RS06650 (1367104) 1367104..1368138 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
H9201_RS06655 (1368351) 1368351..1369064 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H9201_RS06660 (1369218) 1369218..1369445 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9201_RS06665 (1369445) 1369445..1369843 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
H9201_RS06670 (1369990) 1369990..1370853 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H9201_RS06675 (1370868) 1370868..1372883 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
H9201_RS06680 (1372957) 1372957..1373655 + 699 WP_000679812.1 esterase -
H9201_RS06685 (1373736) 1373736..1373936 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T171528 WP_000911330.1 NZ_CP060924:1369445-1369843 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T171528 NZ_CP077963:c13672-13289 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT171528 WP_000450524.1 NZ_CP060924:1369218-1369445 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT171528 NZ_CP077963:c13890-13669 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References