Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 804410..805242 | Replicon | chromosome |
| Accession | NZ_CP060924 | ||
| Organism | Escherichia coli strain EC14 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | H9201_RS03915 | Protein ID | WP_000854753.1 |
| Coordinates | 804410..804784 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | H9201_RS03920 | Protein ID | WP_219412244.1 |
| Coordinates | 804874..805242 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9201_RS03875 (799449) | 799449..799898 | + | 450 | Protein_761 | type II secretion system protein GspC | - |
| H9201_RS03880 (799928) | 799928..800710 | + | 783 | Protein_762 | secretin N-terminal domain-containing protein | - |
| H9201_RS03885 (800703) | 800703..801053 | + | 351 | Protein_763 | type II secretion system protein GspK | - |
| H9201_RS03890 (801050) | 801050..802228 | + | 1179 | WP_241415860.1 | type II secretion system protein GspL | - |
| H9201_RS03895 (802230) | 802230..802766 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| H9201_RS03900 (803048) | 803048..803619 | - | 572 | Protein_766 | DUF4942 domain-containing protein | - |
| H9201_RS03905 (803716) | 803716..803913 | - | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| H9201_RS03910 (803925) | 803925..804413 | - | 489 | WP_000777545.1 | DUF5983 family protein | - |
| H9201_RS03915 (804410) | 804410..804784 | - | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| H9201_RS03920 (804874) | 804874..805242 | - | 369 | WP_219412244.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H9201_RS03925 (805405) | 805405..805626 | - | 222 | WP_001405861.1 | DUF987 domain-containing protein | - |
| H9201_RS03930 (805695) | 805695..806171 | - | 477 | WP_001186724.1 | RadC family protein | - |
| H9201_RS03935 (806187) | 806187..806672 | - | 486 | WP_112917491.1 | antirestriction protein | - |
| H9201_RS03940 (806727) | 806727..807545 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| H9201_RS03945 (807645) | 807645..807878 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| H9201_RS03950 (807957) | 807957..808412 | - | 456 | WP_072645706.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T171525 WP_000854753.1 NZ_CP060924:c804784-804410 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T171525 NZ_CP077960:1189274-1189420 [Mammaliicoccus sciuri]
GTGAGAAATTTGAATAAAAATCTAGAAGAAGAAAATGAAATGGTTCAAGACCTAGAAGATGTTAAAGAACTAGGTAAAGA
AATGGAACAAATATCAGAACAAAATGATGAAGCTTTTGAAGAAAAGAAATCTGAACAAGAGTCTTAA
GTGAGAAATTTGAATAAAAATCTAGAAGAAGAAAATGAAATGGTTCAAGACCTAGAAGATGTTAAAGAACTAGGTAAAGA
AATGGAACAAATATCAGAACAAAATGATGAAGCTTTTGAAGAAAAGAAATCTGAACAAGAGTCTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13680.51 Da Isoelectric Point: 6.8270
>AT171525 WP_219412244.1 NZ_CP060924:c805242-804874 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADHAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADHAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT171525 NZ_CP077960:1188670-1189269 [Mammaliicoccus sciuri]
ATGGCTTTAAACTTTAAAGTATTTGAAACAAAAGATATTGCTGCACGATATGCTGCAGATGTAGTTCGCAAACAATTTAA
TTCAGATAGCACTTCAGTTGTCGGTGTTCATTTAGAAGCAGAACAAACATCATTTTTCGATGAACTATTAGATGATGTTA
AGAAAAATCCTGTGAACTTCAGTCAAATTCATATTTTAGACTTTGACGGTAAAGAAGATTATTACACAGAATTAGGTGTC
CCAGCTAAACAAGTATTAAAAACTGATGTCGGTAGTGATGTTGAAGCATTTATTAAAGAAAAAGTGAATACTGACAAAAA
GAAAAACAAATTGATGTTAGATGTTGTCACTTTAACTGAAGATAGCAGAACGGGATTAGACTATGATCAAGCAATTCACC
CAGCAAGAGAAGTTATCGTACTTGTCACTGGTAAAGAAAAAGCTAAAGCAGTAAGTCAGTTATATCAAGAACCTGCAAAT
GGTTCTGTTGAATCCGCTAAATTAAAACAACATAGAATGGTAACAGTTGTATTAGATAATGAAGCGGCACAAGGGTTACC
TGAAGACGTTAGATCTTACTTCTCAATTCAATTTTCATAA
ATGGCTTTAAACTTTAAAGTATTTGAAACAAAAGATATTGCTGCACGATATGCTGCAGATGTAGTTCGCAAACAATTTAA
TTCAGATAGCACTTCAGTTGTCGGTGTTCATTTAGAAGCAGAACAAACATCATTTTTCGATGAACTATTAGATGATGTTA
AGAAAAATCCTGTGAACTTCAGTCAAATTCATATTTTAGACTTTGACGGTAAAGAAGATTATTACACAGAATTAGGTGTC
CCAGCTAAACAAGTATTAAAAACTGATGTCGGTAGTGATGTTGAAGCATTTATTAAAGAAAAAGTGAATACTGACAAAAA
GAAAAACAAATTGATGTTAGATGTTGTCACTTTAACTGAAGATAGCAGAACGGGATTAGACTATGATCAAGCAATTCACC
CAGCAAGAGAAGTTATCGTACTTGTCACTGGTAAAGAAAAAGCTAAAGCAGTAAGTCAGTTATATCAAGAACCTGCAAAT
GGTTCTGTTGAATCCGCTAAATTAAAACAACATAGAATGGTAACAGTTGTATTAGATAATGAAGCGGCACAAGGGTTACC
TGAAGACGTTAGATCTTACTTCTCAATTCAATTTTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|