Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4588592..4589187 Replicon chromosome
Accession NZ_CP060919
Organism Escherichia coli strain EC15

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H9202_RS22575 Protein ID WP_000239579.1
Coordinates 4588592..4588942 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H9202_RS22580 Protein ID WP_001223208.1
Coordinates 4588936..4589187 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9202_RS22555 (4583868) 4583868..4584890 - 1023 WP_001296689.1 ABC transporter permease -
H9202_RS22560 (4584904) 4584904..4586406 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
H9202_RS22565 (4586716) 4586716..4587672 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H9202_RS22570 (4587982) 4587982..4588512 + 531 WP_000055072.1 inorganic diphosphatase -
H9202_RS22575 (4588592) 4588592..4588942 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H9202_RS22580 (4588936) 4588936..4589187 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H9202_RS22585 (4589400) 4589400..4589741 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H9202_RS22590 (4589744) 4589744..4593523 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T171517 WP_000239579.1 NZ_CP060919:c4588942-4588592 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T171517 NZ_CP077941:2024219-2024488 [Halomonas profundi]
ATGCTTGTCCTTGAATATTCAGCTCAATTTAAAAAAGATTTCAAAAAAATTGCTAAAATGCCGATTCCTGAAATTTTGGA
AGTTGGGGATATCATCTCCAAGCTTCAGCGCGGCGAATCACTCTCGCTAAAAAATGTTGACCATCCTCTGAGTGGAAATT
GGCTCGGCTTTAGAGATTGCCACATCAAGCCAGATCTCGTTTTAATCTACCGAATTGATAATAGTACCCTGCAACTTGCT
CGAATTGGCTCTCATAGCGAAGTTTTCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT171517 WP_001223208.1 NZ_CP060919:c4589187-4588936 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT171517 NZ_CP077941:2023891-2024232 [Halomonas profundi]
ATGATTCAACTAAGTGCTACAATGTATGACATTGCAACACACTCTGGAGTGGTTATCATGAAAAGCGAAATGCTTAGCAC
ACGCATAGATCATGACACAAAAGTCGCATTTACCAACATCTGTGATGACCTCGGGCTAAGTCCATCTCAGGCACTCAAGC
TTTTTGCGCGTGCCGTTATAAATCATGGCGGTATACCTTTTGAGCTTAAAGCACGCCAACCAAATGAAACAACGGCGGCT
GCAATTCAGGAACTAGTAGAAGGTAAAGGCCAGCGAAGCAAGTCTCTTGATAACATGTTAAATGACTTAACTGAAGGCAA
AGTAGTCAATGCTTGTCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References