Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4502853..4503688 Replicon chromosome
Accession NZ_CP060919
Organism Escherichia coli strain EC15

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag H9202_RS22115 Protein ID WP_000854759.1
Coordinates 4502853..4503230 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag H9202_RS22120 Protein ID WP_001295723.1
Coordinates 4503320..4503688 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9202_RS22090 (4499242) 4499242..4500783 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
H9202_RS22095 (4501377) 4501377..4501553 - 177 Protein_4321 helix-turn-helix domain-containing protein -
H9202_RS22100 (4501920) 4501920..4502069 - 150 Protein_4322 hypothetical protein -
H9202_RS22105 (4502175) 4502175..4502351 - 177 WP_000839286.1 DUF957 domain-containing protein -
H9202_RS22110 (4502368) 4502368..4502856 - 489 WP_000761690.1 DUF5983 family protein -
H9202_RS22115 (4502853) 4502853..4503230 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
H9202_RS22120 (4503320) 4503320..4503688 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9202_RS22125 (4503851) 4503851..4504072 - 222 WP_000692345.1 DUF987 domain-containing protein -
H9202_RS22130 (4504135) 4504135..4504611 - 477 WP_001186775.1 RadC family protein -
H9202_RS22135 (4504627) 4504627..4505100 - 474 WP_000855059.1 antirestriction protein -
H9202_RS22140 (4505440) 4505440..4506258 - 819 WP_042631095.1 DUF932 domain-containing protein -
H9202_RS22145 (4506376) 4506376..4506571 - 196 Protein_4331 DUF905 family protein -
H9202_RS22150 (4506642) 4506642..4506833 - 192 Protein_4332 autotransporter domain-containing protein -
H9202_RS22155 (4506917) 4506917..4507939 + 1023 WP_000255946.1 IS21-like element IS100 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaCTX-M-55 cheD / fimH / fimG / fimF / fimD / fimC / fimI / fimA / fimE / fimB 4339202..4508319 169117
- flank IS/Tn - - 4499242..4500783 1541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T171516 WP_000854759.1 NZ_CP060919:c4503230-4502853 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T171516 NZ_CP077936:c2587552-2587445 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT171516 WP_001295723.1 NZ_CP060919:c4503688-4503320 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171516 NZ_CP077936:2587368-2587428 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References