Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2785480..2786118 Replicon chromosome
Accession NZ_CP060914
Organism Escherichia coli strain EC18

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H9203_RS13755 Protein ID WP_000813794.1
Coordinates 2785942..2786118 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H9203_RS13750 Protein ID WP_001270286.1
Coordinates 2785480..2785896 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9203_RS13730 (2780632) 2780632..2781573 - 942 WP_072649490.1 ABC transporter permease -
H9203_RS13735 (2781574) 2781574..2782587 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
H9203_RS13740 (2782605) 2782605..2783750 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
H9203_RS13745 (2783995) 2783995..2785401 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
H9203_RS13750 (2785480) 2785480..2785896 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H9203_RS13755 (2785942) 2785942..2786118 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H9203_RS13760 (2786340) 2786340..2786570 + 231 WP_000494244.1 YncJ family protein -
H9203_RS13765 (2786662) 2786662..2788623 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H9203_RS13770 (2788696) 2788696..2789232 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H9203_RS13775 (2789324) 2789324..2790499 + 1176 WP_001236215.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T171481 WP_000813794.1 NZ_CP060914:c2786118-2785942 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T171481 NZ_CP077928:c1437196-1436945 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGATACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGATCTTGATGAAGCAGTAGGTATTATGGTAAGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT171481 WP_001270286.1 NZ_CP060914:c2785896-2785480 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT171481 NZ_CP077928:c1436955-1436782 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References