Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1041530..1042328 | Replicon | chromosome |
| Accession | NZ_CP060914 | ||
| Organism | Escherichia coli strain EC18 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | H9203_RS05150 | Protein ID | WP_000854735.1 |
| Coordinates | 1041530..1041907 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M1EW42 |
| Locus tag | H9203_RS05155 | Protein ID | WP_032153712.1 |
| Coordinates | 1041954..1042328 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9203_RS05110 (1036746) | 1036746..1037096 | + | 351 | Protein_992 | type II secretion system protein GspK | - |
| H9203_RS05115 (1037093) | 1037093..1038271 | + | 1179 | WP_000094974.1 | type II secretion system protein GspL | - |
| H9203_RS05120 (1038273) | 1038273..1038809 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| H9203_RS05125 (1039224) | 1039224..1039550 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H9203_RS05130 (1039547) | 1039547..1039810 | - | 264 | WP_025492088.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| H9203_RS05135 (1039882) | 1039882..1040748 | - | 867 | WP_032153714.1 | DUF4942 domain-containing protein | - |
| H9203_RS05140 (1040833) | 1040833..1041030 | - | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| H9203_RS05145 (1041042) | 1041042..1041533 | - | 492 | WP_023155722.1 | DUF5983 family protein | - |
| H9203_RS05150 (1041530) | 1041530..1041907 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| H9203_RS05155 (1041954) | 1041954..1042328 | - | 375 | WP_032153712.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| H9203_RS05160 (1042408) | 1042408..1042629 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| H9203_RS05165 (1042698) | 1042698..1043174 | - | 477 | WP_001186715.1 | RadC family protein | - |
| H9203_RS05170 (1043190) | 1043190..1043675 | - | 486 | WP_032153711.1 | antirestriction protein | - |
| H9203_RS05175 (1043767) | 1043767..1044585 | - | 819 | WP_001234693.1 | DUF932 domain-containing protein | - |
| H9203_RS05180 (1044676) | 1044676..1044885 | - | 210 | WP_023155727.1 | DUF905 family protein | - |
| H9203_RS05185 (1044915) | 1044915..1045592 | - | 678 | WP_023155728.1 | hypothetical protein | - |
| H9203_RS05190 (1045711) | 1045711..1046595 | - | 885 | WP_024166630.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | papI / papB | 1039547..1108041 | 68494 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T171467 WP_000854735.1 NZ_CP060914:c1041907-1041530 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T171467 NZ_CP077925:c2206968-2206759 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 13697.51 Da Isoelectric Point: 6.6240
>AT171467 WP_032153712.1 NZ_CP060914:c1042328-1041954 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT171467 NZ_CP077925:c2207273-2206980 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M1EW42 |