Detailed information of TA system TA171450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2437585..2439173
• Replicon: chromosome
• Accession: NZ_CP060908
• Organism: Escherichia coli strain EC19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: H9204_RS11800
• Protein ID: WP_001125463.1
• Coordinates: 2437851..2439173 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H9204_RS11795
• Protein ID: WP_001296726.1
• Coordinates: 2437585..2437851 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9204_RS11795 (2437585)	2437585..2437851	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
H9204_RS11800 (2437851)	2437851..2439173	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
H9204_RS11805 (2439485)	2439485..2439693	+	209	Protein_2316	AraC family transcriptional regulator	-
H9204_RS11810 (2440125)	2440125..2440688	+	564	WP_001373493.1	type 1 fimbrial major subunit FimA	-
H9204_RS11815 (2441049)	2441049..2441759	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2437585..2455009	17424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T171450 WP_001125463.1 NZ_CP060908:2437851-2439173 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T171450 NZ_CP077923:641243-641545 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATGGCAAGATACGTTGTATTGATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
CCCGATACCAGTAGATGAAGAAAGTATTTCATCGATCATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCAGAAAGTAAATATAGAAAAGCAACAGGA
CAAGCACCTATCAAAGAAGTGATGACACCTACAAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT171450 WP_001296726.1 NZ_CP060908:2437585-2437851 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT171450 NZ_CP077923:c641163-641097 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0