Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1352069..1352694 Replicon chromosome
Accession NZ_CP060908
Organism Escherichia coli strain EC19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H9204_RS06540 Protein ID WP_000911330.1
Coordinates 1352296..1352694 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H9204_RS06535 Protein ID WP_000450524.1
Coordinates 1352069..1352296 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9204_RS06510 (1347872) 1347872..1348342 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H9204_RS06515 (1348342) 1348342..1348914 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H9204_RS06520 (1349060) 1349060..1349938 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H9204_RS06525 (1349955) 1349955..1350989 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H9204_RS06530 (1351202) 1351202..1351915 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H9204_RS06535 (1352069) 1352069..1352296 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9204_RS06540 (1352296) 1352296..1352694 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
H9204_RS06545 (1352841) 1352841..1353704 + 864 WP_001267507.1 neutral zinc metallopeptidase -
H9204_RS06550 (1353719) 1353719..1355734 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
H9204_RS06555 (1355808) 1355808..1356506 + 699 WP_000679823.1 esterase -
H9204_RS06560 (1356616) 1356616..1356816 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T171439 WP_000911330.1 NZ_CP060908:1352296-1352694 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T171439 NZ_CP077922:c1378305-1378198 [Staphylococcus aureus]
GTGGTATCTATTGTGGATGCACTAAATTTGATGTTTAGTTTCGGTATGTTTATCGTTACTTTACTAGGTTTAGTCATCGC
AATTGTTAAATTAAGTCACAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT171439 WP_000450524.1 NZ_CP060908:1352069-1352296 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT171439 NZ_CP077922:1378079-1378145 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References