Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 326830..327416 Replicon chromosome
Accession NZ_CP060908
Organism Escherichia coli strain EC19

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag H9204_RS01485 Protein ID WP_042014162.1
Coordinates 326830..327060 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H9204_RS01490 Protein ID WP_000593555.1
Coordinates 327057..327416 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9204_RS01475 (322867) 322867..325602 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
H9204_RS01480 (325602) 325602..326726 + 1125 WP_001314210.1 ABC transporter permease -
H9204_RS01485 (326830) 326830..327060 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
H9204_RS01490 (327057) 327057..327416 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H9204_RS01495 (327536) 327536..327937 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H9204_RS01500 (327943) 327943..328749 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
H9204_RS01505 (328746) 328746..329510 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
H9204_RS01510 (329510) 329510..330343 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
H9204_RS01515 (330340) 330340..331284 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T171432 WP_042014162.1 NZ_CP060908:326830-327060 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T171432 NZ_CP077921:1115824-1116012 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT171432 WP_000593555.1 NZ_CP060908:327057-327416 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT171432 NZ_CP077921:1115535-1115795 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References