Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2766327..2767167 Replicon chromosome
Accession NZ_CP060899
Organism Escherichia coli strain EC21

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag H9206_RS13610 Protein ID WP_000854686.1
Coordinates 2766327..2766710 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0YJ34
Locus tag H9206_RS13615 Protein ID WP_001360163.1
Coordinates 2766787..2767167 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9206_RS13570 (2761329) 2761329..2761820 - 492 WP_001297187.1 DUF1097 domain-containing protein -
H9206_RS13575 (2761922) 2761922..2762476 - 555 WP_001001902.1 molecular chaperone YcdY -
H9206_RS13580 (2762500) 2762500..2763237 - 738 WP_000283664.1 zinc-binding phosphatase -
H9206_RS13585 (2763292) 2763292..2764230 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
H9206_RS13595 (2764701) 2764701..2765543 - 843 WP_001274547.1 DUF4942 domain-containing protein -
H9206_RS13600 (2765628) 2765628..2765825 - 198 WP_000839253.1 DUF957 domain-containing protein -
H9206_RS13605 (2765842) 2765842..2766330 - 489 WP_001054233.1 DUF5983 family protein -
H9206_RS13610 (2766327) 2766327..2766710 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
H9206_RS13615 (2766787) 2766787..2767167 - 381 WP_001360163.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9206_RS13620 (2767178) 2767178..2767861 - 684 WP_000086769.1 hypothetical protein -
H9206_RS13625 (2767880) 2767880..2768101 - 222 WP_000692298.1 DUF987 domain-containing protein -
H9206_RS13630 (2768164) 2768164..2768640 - 477 WP_001186726.1 RadC family protein -
H9206_RS13635 (2768656) 2768656..2769141 - 486 WP_000214307.1 antirestriction protein -
H9206_RS13640 (2769233) 2769233..2770051 - 819 WP_001234732.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T171389 WP_000854686.1 NZ_CP060899:c2766710-2766327 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T171389 NZ_CP077911:c2328758-2328654 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13950.74 Da        Isoelectric Point: 5.0823

>AT171389 WP_001360163.1 NZ_CP060899:c2767167-2766787 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT171389 NZ_CP077911:2328542-2328597 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0YJ34

References