Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1270142..1270767 Replicon chromosome
Accession NZ_CP060899
Organism Escherichia coli strain EC21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H9206_RS06160 Protein ID WP_000911330.1
Coordinates 1270369..1270767 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H9206_RS06155 Protein ID WP_000450524.1
Coordinates 1270142..1270369 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9206_RS06130 (1265945) 1265945..1266415 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H9206_RS06135 (1266415) 1266415..1266987 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H9206_RS06140 (1267133) 1267133..1268011 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H9206_RS06145 (1268028) 1268028..1269062 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
H9206_RS06150 (1269275) 1269275..1269988 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H9206_RS06155 (1270142) 1270142..1270369 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9206_RS06160 (1270369) 1270369..1270767 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
H9206_RS06165 (1270914) 1270914..1271777 + 864 WP_001267498.1 neutral zinc metallopeptidase -
H9206_RS06170 (1271792) 1271792..1273807 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
H9206_RS06175 (1273881) 1273881..1274579 + 699 WP_000679812.1 esterase -
H9206_RS06180 (1274660) 1274660..1274860 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T171377 WP_000911330.1 NZ_CP060899:1270369-1270767 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T171377 NZ_CP077908:c1239401-1239192 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT171377 WP_000450524.1 NZ_CP060899:1270142-1270369 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT171377 NZ_CP077908:c1239706-1239413 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References