Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4240617..4241212 Replicon chromosome
Accession NZ_CP060892
Organism Escherichia coli strain EC22

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H9207_RS20515 Protein ID WP_000239579.1
Coordinates 4240617..4240967 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H9207_RS20520 Protein ID WP_001223208.1
Coordinates 4240961..4241212 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9207_RS20495 (4236063) 4236063..4237085 - 1023 WP_001295197.1 ABC transporter permease -
H9207_RS20500 (4237099) 4237099..4238601 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
H9207_RS20505 (4238741) 4238741..4239697 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H9207_RS20510 (4240007) 4240007..4240537 + 531 WP_000055072.1 inorganic diphosphatase -
H9207_RS20515 (4240617) 4240617..4240967 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H9207_RS20520 (4240961) 4240961..4241212 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H9207_RS20525 (4241424) 4241424..4241765 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H9207_RS20530 (4241768) 4241768..4245547 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T171368 WP_000239579.1 NZ_CP060892:c4240967-4240617 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T171368 NZ_CP077899:1970615-1970710 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT171368 WP_001223208.1 NZ_CP060892:c4241212-4240961 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT171368 NZ_CP077899:c1970795-1970738 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References