171350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 930846..931500 Replicon chromosome
Accession NZ_CP060892
Organism Escherichia coli strain EC22

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag H9207_RS04565 Protein ID WP_000244777.1
Coordinates 931093..931500 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H9207_RS04560 Protein ID WP_000354046.1
Coordinates 930846..931112 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9207_RS04535 (926015) 926015..926758 + 744 WP_000951964.1 SDR family oxidoreductase -
H9207_RS04540 (926815) 926815..928248 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
H9207_RS04545 (928293) 928293..928604 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
H9207_RS04550 (928768) 928768..929427 + 660 WP_000250274.1 hemolysin III family protein -
H9207_RS04555 (929623) 929623..930603 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H9207_RS04560 (930846) 930846..931112 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H9207_RS04565 (931093) 931093..931500 + 408 WP_000244777.1 protein YgfX Toxin
H9207_RS04570 (931540) 931540..932061 - 522 WP_001055874.1 flavodoxin FldB -
H9207_RS04575 (932173) 932173..933069 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H9207_RS04580 (933094) 933094..933804 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9207_RS04585 (933810) 933810..935543 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T171350 WP_000244777.1 NZ_CP060892:931093-931500 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T171350 NZ_CP077894:c2398633-2398529 [Staphylococcus aureus]
CTGTTACTCCTAGAAAGGAATAGCATGTCTGATTTTGAAATGCTAATGGTTGTATTAACGATCATCGGTTTAGTATTAAT
CAGTAATCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT171350 WP_000354046.1 NZ_CP060892:930846-931112 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171350 NZ_CP077894:2398415-2398470 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References