171349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 797494..798326 Replicon chromosome
Accession NZ_CP060892
Organism Escherichia coli strain EC22

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag H9207_RS03875 Protein ID WP_000854765.1
Coordinates 797494..797868 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag H9207_RS03880 Protein ID WP_001295723.1
Coordinates 797958..798326 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9207_RS03840 (792572) 792572..793171 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
H9207_RS03845 (793174) 793174..794151 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
H9207_RS03850 (794148) 794148..795326 + 1179 WP_000094991.1 type II secretion system protein GspL -
H9207_RS03855 (795328) 795328..795864 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
H9207_RS03860 (796145) 796145..796987 - 843 WP_022645115.1 DUF4942 domain-containing protein -
H9207_RS03865 (797072) 797072..797266 - 195 WP_024181941.1 DUF957 domain-containing protein -
H9207_RS03870 (797291) 797291..797494 - 204 WP_001398797.1 DUF5983 family protein -
H9207_RS03875 (797494) 797494..797868 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
H9207_RS03880 (797958) 797958..798326 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9207_RS03885 (798489) 798489..798710 - 222 WP_000692341.1 DUF987 domain-containing protein -
H9207_RS03890 (798773) 798773..799249 - 477 WP_001186774.1 RadC family protein -
H9207_RS03895 (799265) 799265..799744 - 480 WP_057109541.1 antirestriction protein -
H9207_RS03900 (800010) 800010..800828 - 819 WP_001175165.1 DUF932 domain-containing protein -
H9207_RS03905 (800918) 800918..801151 - 234 WP_001278293.1 DUF905 family protein -
H9207_RS03910 (801157) 801157..801834 - 678 WP_001097302.1 hypothetical protein -
H9207_RS03915 (801982) 801982..802662 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T171349 WP_000854765.1 NZ_CP060892:c797868-797494 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171349 NZ_CP077894:c1438751-1438656 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT171349 WP_001295723.1 NZ_CP060892:c798326-797958 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171349 NZ_CP077894:1438571-1438628 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References