Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3586433..3587051 Replicon chromosome
Accession NZ_CP060885
Organism Escherichia coli strain EC24

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H9208_RS17465 Protein ID WP_001291435.1
Coordinates 3586833..3587051 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H9208_RS17460 Protein ID WP_000344800.1
Coordinates 3586433..3586807 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9208_RS17450 (3581522) 3581522..3582715 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9208_RS17455 (3582738) 3582738..3585887 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H9208_RS17460 (3586433) 3586433..3586807 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H9208_RS17465 (3586833) 3586833..3587051 + 219 WP_001291435.1 HHA domain-containing protein Toxin
H9208_RS17470 (3587223) 3587223..3587774 + 552 WP_000102568.1 maltose O-acetyltransferase -
H9208_RS17475 (3587890) 3587890..3588360 + 471 WP_000136192.1 YlaC family protein -
H9208_RS17480 (3588524) 3588524..3590074 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H9208_RS17485 (3590116) 3590116..3590469 - 354 WP_000878140.1 DUF1428 domain-containing protein -
H9208_RS17495 (3590848) 3590848..3591159 + 312 WP_000409911.1 MGMT family protein -
H9208_RS17500 (3591190) 3591190..3591762 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T171334 WP_001291435.1 NZ_CP060885:3586833-3587051 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171334 NZ_CP077889:c2554222-2554118 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT171334 WP_000344800.1 NZ_CP060885:3586433-3586807 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT171334 NZ_CP077889:2554024-2554062 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References