171306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3511860..3512478 Replicon chromosome
Accession NZ_CP060880
Organism Escherichia coli strain EC26

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H9209_RS17095 Protein ID WP_001291435.1
Coordinates 3512260..3512478 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H9209_RS17090 Protein ID WP_000344800.1
Coordinates 3511860..3512234 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9209_RS17080 (3506949) 3506949..3508142 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9209_RS17085 (3508165) 3508165..3511314 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
H9209_RS17090 (3511860) 3511860..3512234 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H9209_RS17095 (3512260) 3512260..3512478 + 219 WP_001291435.1 HHA domain-containing protein Toxin
H9209_RS17100 (3512650) 3512650..3513201 + 552 WP_000102564.1 maltose O-acetyltransferase -
H9209_RS17105 (3513317) 3513317..3513787 + 471 WP_000136192.1 YlaC family protein -
H9209_RS17110 (3513951) 3513951..3515501 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H9209_RS17115 (3515543) 3515543..3515896 - 354 WP_000878140.1 DUF1428 domain-containing protein -
H9209_RS17125 (3516275) 3516275..3516586 + 312 WP_000409911.1 MGMT family protein -
H9209_RS17130 (3516617) 3516617..3517189 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T171306 WP_001291435.1 NZ_CP060880:3512260-3512478 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171306 NZ_CP077880:1706082-1706270 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT171306 WP_000344800.1 NZ_CP060880:3511860-3512234 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT171306 NZ_CP077880:1705793-1706053 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References