Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2334070..2334596 Replicon chromosome
Accession NZ_CP060880
Organism Escherichia coli strain EC26

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H9209_RS11375 Protein ID WP_000323025.1
Coordinates 2334309..2334596 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H9209_RS11370 Protein ID WP_000534858.1
Coordinates 2334070..2334309 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9209_RS11335 (2329429) 2329429..2329776 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
H9209_RS11340 (2329773) 2329773..2330177 - 405 WP_000839179.1 transposase -
H9209_RS11345 (2330399) 2330399..2330820 + 422 Protein_2227 hypothetical protein -
H9209_RS11350 (2331476) 2331476..2332498 + 1023 Protein_2228 ISNCY family transposase -
H9209_RS11355 (2332619) 2332619..2332768 + 150 WP_011443592.1 protein YdfW -
H9209_RS11360 (2333205) 2333205..2333537 - 333 WP_001301033.1 FlxA-like family protein -
H9209_RS11365 (2333740) 2333740..2334045 - 306 WP_001326990.1 protein YdfV -
H9209_RS11370 (2334070) 2334070..2334309 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H9209_RS11375 (2334309) 2334309..2334596 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H9209_RS11380 (2334668) 2334668..2334823 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H9209_RS11385 (2335040) 2335040..2335291 + 252 WP_000980994.1 protein Rem -
H9209_RS11390 (2335358) 2335358..2335636 + 279 WP_012304870.1 hypothetical protein -
H9209_RS11395 (2335638) 2335638..2336687 + 1050 WP_001265199.1 DUF968 domain-containing protein -
H9209_RS11400 (2336701) 2336701..2337171 + 471 Protein_2238 antitermination protein -
H9209_RS11405 (2337226) 2337226..2337923 + 698 WP_106423973.1 IS1 family transposase -
H9209_RS11410 (2337937) 2337937..2338041 - 105 Protein_2240 putative zinc-binding protein YnfU -
H9209_RS11415 (2338261) 2338261..2338476 + 216 WP_000839590.1 phage lysis protein EssD -
H9209_RS11420 (2338481) 2338481..2338792 + 312 WP_000189916.1 YdfR family protein -
H9209_RS11425 (2338789) 2338789..2339322 + 534 WP_001092971.1 lysozyme -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2306755..2370245 63490
- flank IS/Tn - - 2337630..2337923 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T171303 WP_000323025.1 NZ_CP060880:2334309-2334596 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T171303 NZ_CP077880:575494-575646 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT171303 WP_000534858.1 NZ_CP060880:2334070-2334309 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT171303 NZ_CP077880:574870-575469 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References